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OBJECTIVES Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN Retrospective multinational study including SCN diagnosed between 1990 and 2014. RESULTS 2622 patients were included.(More)
Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances in knowledge and practice about the(More)
OBJECTIVES The role of human papillomavirus (HPV) in Barrett's esophagus (BE) remains unclear. The few studies that have previously investigated HPV and esophageal adenocarcinoma (EAC) or BE have produced either negative data or positive results of doubtful clinical/etiological significance or have detected only low-risk HPV types. We therefore(More)
Pregnant guinea pigs were fed on one of three diets: a commercial low-fat diet or a high-fat diet containing either maize oil or beef dripping. The young were killed at birth, the brain removed and dissected into three regions; the cerebellum, cerebrum and stem. The fatty acid composition of the major phospholipid classes, phosphatidylcholine and(More)
Pregnant guinea pigs were fed one of three diets: a control low-fat diet or a high-fat diet containing maize oil or beef tallow. Offspring were reared on the same diets as their mothers. At 12 weeks of age some animals were killed; others had their food intake restricted for 2 weeks and were then killed. Body weight, weight of various adipose tissue depots(More)