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MOTIVATION In silico experiments in bioinformatics involve the co-ordinated use of computational tools and information repositories. A growing number of these resources are being made available with programmatic access in the form of Web services. Bioinformatics scientists will need to orchestrate these Web services in workflows as part of their analyses.(More)
SUMMARY Life sciences research is based on individuals, often with diverse skills, assembled into research groups. These groups use their specialist expertise to address scientific problems. The in silico experiments undertaken by these research groups can be represented as workflows involving the coordinated use of analysis programs and information(More)
Like experiments performed at a laboratory bench, the data associated with an e-Science experiment are of reduced value if other scientists are not able to identify the origin, or provenance, of those data. Provenance information is essential if experiments are to be validated and verified by others, or even by those who originally performed them. In this(More)
Workflow techniques form an important part of in-silico experimentation within the bioinformatics domain and potentially allow the eScientist to describe and enact their experimental processes in a structured, repeatable and verifiable way. Bioinformaticians routinely use Web-based resources within their in-silico experiments. However, the use of current(More)
The move towards supporting more autonomous systems, where decisions are made without direct user intervention, and more complex operating scenarios, where services from multiple organisations form temporary ties to solve particular problems, creates new security challenges. This paper argues that the answers should combine the use of conventional security(More)
As web service technology matures there is growing interest in exploiting workflow techniques to coordinate web services. Bioinformaticians are a user community who combine web resources to perform in <i>silico</i> experiments. These users are scientists and not information technology experts they require workflow solutions that have a low cost of entry for(More)
We introduce Grid Resources for Industrial Applications (GRIA), a project that aims to enable commercial use of the Grid. GRIA enables service providers to rent out spare CPU cycles, and clients to hire those CPU cycles. Web services play a key role in the architecture of GRIA, chiefly through their interoperability and security features - they provide a(More)
OBJECTIVES The GEMSS project is developing a secure Grid infrastructure through which six medical simulations services can be invoked. We examine the legal and security framework within which GEMSS operates. METHODS We provide a legal qualification to the operations performed upon patient data, in view of EU directive 95/46, when using medical(More)