Darlene Miller

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PURPOSE To update the spectrum of ocular fungal isolates and investigate the in vitro efficacy of voriconazole and other antifungals. DESIGN Experimental study. METHODS Microbiology database was scanned and fungal isolates associated with keratitis (419) and endophthalmitis (122) were analyzed for classification and isolate frequency. The Sensititre(More)
PURPOSE To investigate the spectrum of organisms causing culture-proven endophthalmitis and their sensitivities to commonly used antimicrobial agents. DESIGN Retrospective, noncomparative, consecutive case series. METHODS Medical records were reviewed of all patients with culture-proven endophthalmitis at a single institution between January 1, 1996,(More)
Fungal keratitis remains a challenging and often elusive diagnosis in geographic regions where it is endemic. Marred by delays in diagnosis, the sequelae of corneal fungal infections, though preventable, can be irreversible. Recent studies and advances in the arena have broadened the approach and treatment to mycotic keratitis. This review will discuss(More)
PURPOSE To investigate clinical features and visual acuity outcomes associated with endogenous endophthalmitis. DESIGN Retrospective, observational case series. METHODS Twenty-one eyes of 21 patients treated at Bascom Palmer Eye Institute for culture-proven endogenous endophthalmitis between 1996 and 2002 were reviewed. RESULTS Patients were followed(More)
PURPOSE Ocular surface (OS) microbiota contributes to infectious and autoimmune diseases of the eye. Comprehensive analysis of microbial diversity at the OS has been impossible because of the limitations of conventional cultivation techniques. This pilot study aimed to explore true diversity of human OS microbiota using DNA sequencing-based detection and(More)
PURPOSE To assess polymerase chain reaction (PCR) analysis of intraocular fluid as a test for infectious uveitis of the posterior segment in a representative patient population. DESIGN Retrospective, interventional case series. METHODS One hundred and thirty-three patients with possible infectious chorioretinitis underwent PCR testing of aqueous or(More)
PURPOSE To report the causative organisms, management strategies, and visual outcomes in endogenous fungal endophthalmitis. DESIGN Observational case series. METHODS Microbiologic and medical records were reviewed retrospectively for all patients with culture-positive endogenous fungal endophthalmitis between January 1, 1990, and July 1, 2009. RESULTS(More)
malities of dentition. The disease generally progresses until puberty and may regress in adulthood. Radiologically, the radiolucent bony lesions are cystic and multiloculated in nature and are bilateral. These findings in conjunction with the clinical presentation are usually enough to make a diagnosis. Unless surgical intervention is needed for genetic or(More)
The effect on visual function of an optical filter which absorbs essentially all visible wavelengths below 550 nm has been studied in a group of patients with moderate stage cataracts. Using a Snellen-type visual acuity chart with a blue background and orange letters, under both glare and non-glare conditions, the visual acuity of these patients was(More)
PURPOSE To examine the clinical pathology and management of Paecilomyces lilacinus keratitis. DESIGN Observational case series, literature review, and laboratory study. METHODS Characteristics and outcome of 17 patients with laboratory-confirmed Paecilomyces keratitis treated at 2 referral centers were combined with 25 previously reported cases.(More)