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  • Marina R. Picciotto, Nii Armah Addy, Yann S. Mineur, Darlene H. Brunzell
  • Psychology, Medicine
  • Progress in Neurobiology
  • 2008 (First Publication: 1 April 2008)
  • Nicotine can both activate and desensitize/inactivate nicotinic acetylcholine receptors (nAChRs). An ongoing controversy in the field is to what extent the behavioral effects of nicotine result fromExpand
  • Marina R. Picciotto, Barbara J. Caldarone, Darlene H. Brunzell, Venetia Zachariou, Tanya R. Stevens, Sarah L. King
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 2001 (First Publication: 1 November 2001)
  • Nicotinic acetylcholine receptors (nAChRs) in the muscle, autonomic ganglia, and brain are targets for pharmacologically administered nicotine. Several of the subunits that combine to form neuronalExpand
  • Kia J. Jackson, J. Michael McIntosh, Darlene H. Brunzell, Sarah S. Sanjakdar, Mohamad Imad Damaj
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental…
  • 2009 (First Publication: 1 November 2009)
  • The α6 nicotinic acetylcholine receptor (nAChR) subunit is involved in nicotine-stimulated dopamine release in the striatum. It is expressed in brain regions and coexpressed with nAChR subtypesExpand
  • Darlene H. Brunzell, Karen E Boschen, Elizabeth S Hendrick, Patrick M Beardsley, J. Michael McIntosh
  • Medicine, Psychology
  • Neuropsychopharmacology
  • 2010 (First Publication: 1 February 2010)
  • β2 subunit containing nicotinic acetylcholine receptors (β2*nAChRs; asterisk (*) denotes assembly with other subunits) are critical for nicotine self-administration and nicotine-associated dopamineExpand
  • Darlene H. Brunzell
  • Medicine
  • Nicotine & tobacco research : official journal of…
  • 2012 (First Publication: 1 November 2012)
  • INTRODUCTION Nicotine is a major psychoactive ingredient in tobacco yet very few individuals quit smoking with the aid of nicotine replacement therapy. Targeted therapies with more selective actionExpand