Darius K Shayegan

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Schizophrenia is a highly complex disorder characterized by a diversity of symptoms, psychotic and nonpsychotic, that most likely arise from heterogeneous neuroanatomical and neurochemical malfunctions. As with all antipsychotic agents, ziprasidone targets the key hypothetical neurochemical disturbance in psychosis-excessive dopamine neurotransmission at(More)
Understanding common pharmacologic and clinical "class" actions associated with atypical antipsychotics certainly reveals how these agents are alike, but what about unique differences from one agent to another? Atypical antipsychotics are also a heterogeneous group of agents that have complex pharmacologic entities, acting upon multiple dopamine receptors(More)
Schizophrenia is a highly complex disorder characterized by multiple independent domains of disease-namely positive, cognitive, and affective symptom clusters. Functional deficits associated with positive and (more recently) cognitive symptoms, as well as the deconstruction of these symptoms into their corresponding neural circuits, are widely discussed in(More)
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