Dario Terribilini

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PURPOSE To analyze the outcome after low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy for lip cancer. METHODS AND MATERIALS One hundred and three patients with newly diagnosed squamous cell carcinoma of the lip were treated between March 1985 and June 2009 either by HDR (n = 33) or LDR brachytherapy (n = 70). Sixty-eight patients received(More)
OBJECTIVE In this study, the "Progressive Resolution Optimizer PRO3" (Varian Medical Systems) is compared to the previous version "PRO2" with respect to its potential to improve dose sparing to the organs at risk (OAR) and dose coverage of the PTV for head and neck cancer patients. MATERIALS AND METHODS For eight head and neck cancer patients, volumetric(More)
PURPOSE Most dose calculations for HDR brachytherapy treatments are based on the AAPM-TG43 formalism. Because patient's anatomy, heterogeneities, and applicator shielding are not considered, the dose calculation based on this formalism is inaccurate in some cases. Alternatively, collapsed cone (CC) methods as well as Monte Carlo (MC) algorithms belong to(More)
PURPOSE To assess dose rates in volumetric modulated arc therapy (VMAT) plans. METHODS For dose rate analysis, using Monte Carlo methods, dose distributions are calculated in sectors of consecutive DICOM control points and each multiplied with the MU-rate obtaining dose rate distributions for every voxel at every time-point during a treatment fraction.(More)
PURPOSE Treatment plan evaluations in radiotherapy are currently ignoring the dosimetric impact of setup uncertainties. The determination of the robustness for systematic errors is rather computational intensive. This work investigates interpolation schemes to quantify the robustness of treatment plans for systematic errors in terms of efficiency and(More)
BACKGROUND The aim was to evaluate the geometric and corresponding dosimetric differences between two delineation strategies for head and neck tumors neighboring air cavities. METHODS Primary gross and clinical tumor volumes (GTV and CTV) of 14 patients with oropharynx or larynx tumors were contoured using a soft tissue window (S). In a second strategy,(More)
PURPOSE Over the last years, volumetric modulated arc therapy (VMAT) has been widely introduced into clinical routine using a coplanar delivery technique. However, VMAT might be improved by including dynamic couch and collimator rotations, leading to dynamic trajectory radiotherapy (DTRT). In this work the feasibility and the potential benefit of DTRT was(More)
Dose rate is an essential factor in radiobiology. As modern radiotherapy delivery techniques such as volumetric modulated arc therapy (VMAT) introduce dynamic modulation of the dose rate, it is important to assess the changes in dose rate. Both the rate of monitor units per minute (MU rate) and collimation are varied over the course of a fraction, leading(More)
PURPOSE In clinical routine, dose calculation for HDR brachytherapy plans is usually based on the AAPM-TG43 formalism. Because the patient's anatomy is not taken into account, the resulting dose calculation may be inaccurate. Monte Carlo (MC) methods are able to calculate dose distributions accurately, but due to long computation times they are mainly used(More)
PURPOSE In high energy teletherapy, VMC++ is known to be a very accurate and efficient Monte Carlo (MC) code. In principle, the MC method is also a powerful dose calculation tool in other areas in radiation oncology, e.g., brachytherapy or orthovoltage radiotherapy. However, VMC++ is not validated for the low-energy range of such applications. This work(More)
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