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We have recently demonstrated that nicotine administration improves the acquisition and/or memory retention of aged rats in 17-arm radial maze, Lashley III maze, and one-way active avoidance testing. The present study extends our evaluation of nicotine's cognition-enhancing potential by determining the effect of nicotine on acquisition and retention of the(More)
Free radicals and oxidative damage have been implicated in brain aging and several neurodegenerative diseases. The purpose of the present study was to determine whether antioxidants could alleviate age-associated cognitive and motor changes. Aged 24-month-old male Sprague-Dawley rats were treated for 4-5 months with daily i.p. injections of spin-trapping(More)
Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain trauma) are accompanied by hydrocephalus, the present study sought to evaluate the relationship between oxidative stress and the progression of hydrocephalus. Assays for reactive oxygen species (ROS),(More)
Accumulating evidence has implicated free radical production and resultant oxidative damage as a major contributing factor in brain aging and cognitive decline. In the present study, aging 24-month-old rats were chronically treated with the synthetic spin-trapping antioxidant phenyl-alpha-tert-butyl nitrone (PBN) for up to 9.5 months. Chronic PBN treatment(More)
In both young adult and aged rats, we tested the ability of chronically administered nicotine to rescue neocortical neurons from transneuronal degeneration resulting 5 mo after ibotenic acid (IBO) lesioning of the nucleus basalis magnocellularis (NBM). Young adult (2-3 mo-old) and aged (20-22-mo-old) rats were given unilateral infusions of IBO (5 mu g/1 mu(More)
Using the advances of the modern microelectronics technology, the safety-critical systems, such as avionics, can reduce their costs by integrating multiple tasks on one device. This makes such systems essentially mixed-critical, as this brings together different tasks whose error probability requirements may differ by an order of magnitude 10 6. In the(More)
The real-time system design targeting multiprocessor platforms leads to two important complications in real-time scheduling. First, to ensure deterministic processing by communicating tasks the scheduling has to consider precedence constraints. The second complication factor is mixed criticality, i.e., Integration upon a single platform of various(More)
With the proliferation of multi-cores in embedded real-time systems, many industrial applications are being (re-)targeted to multiprocessor platforms. However, exactly reproducible data values at the outputs as function of the data and timing of the inputs is less trivial to realize in multiprocessors, while it can be imperative for various practical(More)
Modern safety-critical systems, such as avionics, tend to be mixed-critical, because integration of different tasks with different assurance requirements can effectively reduce their costs in terms of hardware, at the risk, however to increase the costs for certification, in particular in the context of proving their schedulability. To simplify the(More)