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MOTIVATION The systematic integration of expression profiles and other types of gene information, such as chromosomal localization, ontological annotations and sequence characteristics, still represents a challenge in the gene expression arena. In particular, the analysis of transcriptional data in context of the physical location of genes in a genome(More)
Pediatric acute lymphoblastic leukemia (ALL) comprises genetically distinct subtypes. However, 25% of cases still lack defined genetic hallmarks. To identify genomic aberrancies in childhood ALL patients nonclassifiable by conventional methods, we performed a single nucleotide polymorphisms (SNP) array-based genomic analysis of leukemic cells from 29 cases.(More)
Karyotypic instability, including numerical and structural chromosomal aberrations, represents a distinct feature of multiple myeloma (MM). About 40-50% of patients display hyperdiploidy, defined by recurrent trisomies of non-random chromosomes. To molecularly characterise hyperdiploid (H) and nonhyperdiploid (NH) MM, we analysed the gene expression(More)
AIMS The aim of this work was to evaluate the agreement between temporomandibular joint click sound and MR diagnoses of different disk positions. METHODS One hundred ninety-four (N=194) patients seeking treatment for temporomandibular disorders at the TMD Clinic, Department of Maxillofacial Surgery, University of Padova, Italy, underwent a bilateral(More)
OBJECTIVE The aim of the present study was to evaluate the association between temporomandibular joint (TMJ) effusion and disk displacement by means of magnetic resonance (MR) imaging. METHODS One hundred and ninety-four patients were included in the study and underwent a bilateral MR of the TMJ at both closed mouth and maximum mouth opening positions.(More)
Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This study aimed at investigating the genomic expression(More)
The comparison of stochastic algorithms for optimization requires the use of appropriate statistical methods for the analysis of results. Commonly used parametric tests, like the t-test or ANOVA procedures in experimental design, are based on the assumption that algorithms’ results are normally distributed. However, this assumption is often violated because(More)
Four glycoproteins were separated by SDS-polyacrylamide gel electrophoresis of proteins of human pancreatic juice devoid of free proteolytic activity. The two low molecular weight glycoproteins were isolated and characterized. Protein P19, the precursor family of protein X, was analyzed by its carbohydrate content which seemed to play an important role in(More)