Dario Ambrosini

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Urban morphology and increasing building density play a key role in the overall use of energy and promotion of environmental sustainability. The urban environment causes a local increase of temperature, a phenomenon known as Urban Heat Island (UHI). The purpose of this work is the study of the possible formation of an UHI and the evaluation of its(More)
Alzheimer's disease (AD) is characterized by irreversible and progressive loss of memory and cognition and profound neuronal loss. Current therapeutic strategies for the treatment of AD have been directed to a variety of targets with the aim of reversing or preventing the disease but, unfortunately, the available treatments often produce no significant(More)
A new optoelectronic system is proposed for three-dimensional (3D) texture measurement. It is based on a projection unit in which light, coming from a laser diode coupled to an optical fiber, impinges on a diffractive optical element (DOE) to produce sinusoidal fringes. If the projected fringe pattern is viewed at an angle different from the projection(More)
Tumor homing peptides (THPs) specific for a representative breast cancer cell line (MCF-7) were carefully selected basing on a phage-displayed peptide library freely available on the web, namely the "TumorHoPe: A Database of Tumor Homing Peptides". The selected THPs were synthesized and evaluated in terms of their affinity toward MCF-7 cells. Out of 5(More)
In the artwork conservation field, non contact diagnostic and imaging methods are widely used and most welcomed. In this work a new imaging tool, called Thermal Quasi-Reflectography (TQR), is proposed and demonstrated. It is based on the recording, by suitable procedures, of reflected infrared radiation in the MWIR band (3-5 μm). The technique, simple to(More)
The reduction of building energy consumption requires appropriate planning and design of the building's envelope. In the last years, new innovative materials and construction technologies used in new or refurbished buildings have been developed in order to achieve this objective, which are also needed for reducing greenhouse gases emissions and building(More)
Dopamine (DA) agonists, bearing catechol or phenol rings, are endowed with low oral bioavailability and short effect duration. In this report, the synthesis of novel differently substituted 4-(3-pyridyl)-1,2,3,4-tetrahydroisoquinolines and (1,2,3,4-tetrahydroisoquinolin-4-yl)phenylmethanols as potential non phenolic and non catecholic DA receptor ligands is(More)
Based on the well known biological versatility of the imidazoline nucleus, we prepared the novel derivatives 3a-k inspired by 2-BFI scaffold to assess imidazoline molecules as D(2)-like dopamine receptor ligands. Conservative chemical modifications of the lead structure, such as the introduction of an hydroxy group in the aromatic ring alone or associated(More)
The series of Camerino Symposia present the most recent knowledge and discoveries in the growing field of drug-receptor interactions and the design and mechanisms of drug action. Lead discovery, G protein-coupled receptors (GPCRs) and polypharmacology were the general subjects covered in this Tripartite European Meeting in Medicinal Chemistry chaired by(More)
Receptor-subtype selectivity is an important issue in medicinal chemistry and can become very difficult to achieve if the actual binding pockets of the respective receptors are highly conserved. For such cases, known unselective ligands could be equipped with a spacer that sticks outside the actual orthosteric binding pocket towards the extracellular loops.(More)
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