Darakshan Jabeen Haleem

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BACKGROUND An important goal of current neuroleptic research is to develop antipsychotic compounds with a low incidence of extrapyramidal side effects (EPS). Clozapine, the first of the atypical antipsychotics to be proven effective in treatment-resistant schizophrenia, is reported to produce less EPS than typical neuroleptics, such as haloperidol. (More)
Long term intake of coffee is known to produce anxiety and suppression of appetite. 5- hydroxytryptamine (5-HT) acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor metachloro phenyl piperazine (m-CPP) at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine (a component(More)
Neurochemical research on brain 5-hydroxytryptamine (5-HT; serotonin) and feeding shows that rat brain serotonin metabolism is increased following ingestion of a carbohydrate rich diet to generate a neurochemical signal for the termination of meal. Increased metabolism may not necessarily enhance postsynaptic function; neuropharmacological studies therefore(More)
Stress is defined as a non specific response of body to any physiological and psychological demand. Preclinical studies have shown that an uncontrollable stress condition produces neurochemical and behavioral deficits. The present study was conducted to test the hypothesis that a decrease in the responsiveness of somatodendritic 5-hydroxytryptamine(More)
Background: Fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), has been proposed to be more effective as an antidepressive drug as compared to other SSRIs. After chronic SSRI administration, the increase in synaptic levels of 5-HT leads to desensitization of somatodentritic 5-HT autoreceptors in the raphe nuclei. Chronic stress may alter(More)
Haloperidol is a high potency typical neuroleptic used in the treatment of schizophrenia. Administration of haloperidol produces muscles related side effects commonly known as extrapyramidal effects (EPS). These effects are not produced following the administration of atypical neuroleptics such as clozapine. A severe side effect of clozapine treatment is(More)
OBJECTIVE To investigate the effects of repeated doses of apomorphine in rats exposed to unpredictable chronic mild stress. METHODS The experimental case-control study was conducted in March 2011 at the Department of Biochemistry, University of Karachi, and comprised albino-wistar rats. The experimental animals were exposed to a schedule of unpredictable(More)
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