Dara O'donoghue

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Human respiratory syncytial virus (RSV) causes severe respiratory disease in infants. Airway epithelial cells are the principle targets of RSV infection. However, the mechanisms by which it causes disease are poorly understood. Most RSV pathogenesis data are derived using laboratory-adapted prototypic strains. We hypothesized that such strains may be poorly(More)
The skin is exposed to benzene and its derivatives, prevalent environmental chemicals. They may impair the structural integrity of the skin by increased expression of matrix metalloproteinase 1 (MMP-1; degrades structural collagen) and elastin, synthesized primarily by the dermal fibroblasts. We examined the metabolism of benzene in dermal fibroblasts and(More)
There is a need for reproducible and effective models of pediatric bronchial epithelium to study disease states such as asthma. We aimed to develop, characterize, and differentiate an effective, an efficient, and a reliable three-dimensional model of pediatric bronchial epithelium to test the hypothesis that children with asthma differ in their epithelial(More)
BACKGROUND Sleep-disordered breathing is a common and serious feature of many paediatric conditions and is particularly a problem in children with Down syndrome. Overnight pulse oximetry is recommended as an initial screening test, but it is unclear how overnight oximetry results should be interpreted and how many nights should be recorded. METHODS This(More)
F. Vuille,2 D. O'Donoghue, D. A. H. Buckley, C.-M. Massacand,3 J. E. Solheim, S. Bard, G. Vauclair, O. Giovannini,§ S. O. Kepler, A. Kanaan, J. L. Provencal, M. A. Wood, J. C. Clemens, S. J. Kleinman,¶ M. S. O'Brien, R. E. Nather, D. E. Winget, A. Nitta, E. W. Klumpe, M. H. Montgomery, T. K. Watson, P. A. Bradley, D. J. Sullivan, K. Wu, T. M. K. Marar, S.(More)
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