Daphne Weihs

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During obesity development, preadipocytes proliferate and differentiate into new mature adipocytes, to increase the storage capacity of triglycerides. The morphology of the cells changes during differentiation from an elongated spindle-shape preadipocyte into a rounded, differentiated adipocyte. That change allows efficient packing of spheroidal(More)
A phenomenological model is formulated to model the early stages of tumor formation. The model is based on a cell-based formalism, where each cell is represented as a circle or sphere in two-and three dimensional simulations, respectively. The model takes into account constituent cells, such as epithelial cells, tumor cells, and T-cells that chase the tumor(More)
The diurnal cycle of metabolic rate (MR, J/g·h, based on VO2 and VCO2) was measured in 14 Griffon Vultures (Gyps fulvus), two Hooded Vultures (Necrosyrtes monachus) and one White-backed Vulture (Gyps africanus) at different ambient temperatures (−7 to +34°C). In (so far) three Griffon Vultures the heart rate (HR) and body temperature (Tb) were measured by(More)
Obtaining reliable information on the physical state and ultrastructure of bile is difficult because of its mixed aqueous-lipid composition and thermodynamic metastability. We have used time-lapse cryogenic transmission electron microscopy (cryo-TEM) combined with video-enhanced light microscopy (VELM) to study microstructural evolution in nucleating bile.(More)
We show that metastatic breast cancer cells are quantitatively identifiable from benign cells during adherence onto soft, elastic gels. We identify differences in time-dependent morphology and strength of adherence of single breast cells that are likely related to their malignancy and metastatic potential (MP). Specifically, we compare high and low MP(More)
We review a class of cutting-edge approaches for cytoprotection of cells exposed to assaults such as sustained deformations, chemotherapy, radiotherapy, or ischemia. These approaches will enhance cell survival by mechanically protecting the structure and dynamics of the actin cytoskeleton (CSK). Cortical actin provides structural support to the plasma(More)
The aqueous solutions of the anionic hybrid fluorocarbon/hydrocarbon surfactant sodium 1-oxo-1[4-(tridecafluorohexyl)phenyl]-2-hexanesulfate (FC6HC4) shows peculiar rheological behavior. At 25 degrees C the viscosity vs concentration curve goes successively through a maximum and a minimum, while the viscosity vs temperature curve of the 10 wt% aqueous(More)
Cholesterol crystals are the building blocks of cholesterol gallstones. The exact structure of early-forming crystals is still controversial. We combined cryogenic-temperature transmission electron microscopy with cryogenic-temperature electron diffraction to sequentially study crystal development and structure in nucleating model and native gallbladder(More)
Embryonic stem cells (ESCs) grow into three-dimensional (3D) spheroid structures en-route to tissue growth. In vitro spheroids can be controllably induced on a two-dimensional (2D) substrate with high viability. Here we use a method for inducing pluripotent embryoid body (EB) formation on flat polyacrylamide gels while simultaneously evaluating the dynamic(More)