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Despite the therapeutic efficacy of ibrutinib in chronic lymphocytic leukemia (CLL), complete responses are infrequent, and acquired resistance to Bruton agammaglobulinemia tyrosine kinase (BTK) inhibition is being observed in an increasing number of patients. Combination regimens that increase frequency of complete remissions, accelerate time to remission,(More)
OBJECTIVES We evaluated the bioavailability of Cd in 86 components of 57 jewelry items found to contain high levels of Cd (> 10,000 ppm) by X-ray fluorescence (XRF), using extractions that simulate mouthing or swallowing of jewelry items. METHODS We screened jewelry for Cd content by XRF. Bioavailability was measured in two ways. Items were placed in(More)
Chronic lymphocytic leukemia (CLL) is an incurable disease identified most commonly in elderly patients. Interphase cytogenetics, IGHV status and ZAP70 protein expression/ methylation have been used to risk-stratify patients relative to likelihood of disease progression or treatment assignment when CLL becomes symptomatic Reviewed in 1. microRNAs are short(More)
In mixture toxicity, concentration-effect data are often used to generate conclusions on combined effect. While models of combined effect are available for such assessments, proper fitting of the data is critical to obtaining accurate conclusions. In this study an asymmetry parameter (s) was evaluated for data-fitting and compared with our previous(More)
The introduction of miR profiling of chronic lymphocytic leukemia (CLL) patients with different cytogenetic profiles and responses to therapy has allowed incorporation of important miR-mRNA interactions into the understanding of disease biology. In this study, we performed miR expression analysis using NanoString nCounter to discover differentially(More)
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