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Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall. Expand
Lysosomal Glycosphingolipid Recognition by NKT Cells
It is suggested that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity. Expand
Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins
Mice deficient in prosaposin, the precursor to a family of endosomal lipid transfer proteins (LTP), exhibit specific defects in CD1d-mediated antigen presentation and lack Vα14 NKT cells, which constitute a previously unknown link between lipid metabolism and immunity. Expand
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
The crystal structure of CD1d in complex with a short-chain synthetic variant of α-galactosylceramide elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the α-linkage as a unique pathogen-specific pattern-recognition motif. Expand
BMC Developmental Biology
BMC Developmental Biology is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We doExpand
Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy.
N nanoparticle formulated alpha-galactosylceramide is an attractive immunomodulator for immunotherapy and vaccine development and future studies will be focused on its application as adjuvant for protein and/or peptide antigens. Expand
A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells.
An alpha-galactosyl ceramide with improved solubility over KRN7000 is developed that effectively stains NKT cells, both mouse and human, and stimulates cytokine release at low concentrations. Expand
A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases
The comparison between the new UDP–GlcNAc:βGal β3GnT and the three UDP–Gal:βGlc NAc β-1,3-galactosyltransferase enzymes reveals glycosyltransferases that share conserved sequence motifs though exhibiting inverted donor and acceptor specificities, which suggests that the conserved amino acid motifs likely represent residues required for the catalysis of the glycosidic (β1–3) linkage. Expand
Immunologic glycosphingolipidomics and NKT cell development in mouse thymus.
A glycosphingolipidomics study of mouse thymus, and studied mice mutants which are deficient in beta-hexosaminidase b or alpha-galactosidase A, two glycosidases that are up- and downstream agents of iGb3 turnover, generated a first database for glycospindingolipids expressed in mouse thylacine, which are specifically regulated by rate-limiting glycosidyases. Expand
Regulation of natural killer T‐cell development by deubiquitinase CYLD
It is shown here that CYLD, a tumour suppressor with deubiquitinase function, has a pivotal and cell‐intrinsic function in NKT cell development and is established as a critical regulator of N KT cell development. Expand