Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
- J. Mattner, Kristin L Debord, A. Bendelac
- BiologyNature
- 24 March 2005
Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall.
Lysosomal Glycosphingolipid Recognition by NKT Cells
- Dapeng Zhou, J. Mattner, A. Bendelac
- Biology, ChemistryScience
- 3 December 2004
It is suggested that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity.
Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins
- Dapeng Zhou, C. Cantu, L. Teyton
- Biology, ChemistryScience
- 23 January 2004
Mice deficient in prosaposin, the precursor to a family of endosomal lipid transfer proteins (LTP), exhibit specific defects in CD1d-mediated antigen presentation and lack Vα14 NKT cells, which constitute a previously unknown link between lipid metabolism and immunity.
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
The crystal structure of CD1d in complex with a short-chain synthetic variant of α-galactosylceramide elucidates the basis for the high specificity of these microbial ligands and explains the restriction of the α-linkage as a unique pathogen-specific pattern-recognition motif.
Biosynthesis of the Linkage Region of Glycosaminoglycans
- X. Bai, Dapeng Zhou, J. Brown, B. E. Crawford, T. Hennet, J. Esko
- Biology, ChemistryJournal of Biological Chemistry
- 21 December 2001
The identity of β3GalT6 was confirmed in vivo by siRNA-mediated inhibition of glycosaminoglycan synthesis in HeLa S3 cells, and its localization in the medial Golgi indicates that this is the major site for assembly of the linkage region.
Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation.
- Eliseo F. Castillo, Luis F Acero, Spencer W. Stonier, Dapeng Zhou, K. Schluns
- BiologyBlood
- 7 October 2010
It is reported here that transpresentation of IL-15 by parenchymal cells was crucial for generating normal number of iNKTs in the thymus, whereas both hematopoietic and parenchymal cells regulated iNKT cell numbers in the periphery, particularly in the liver.
BMC Developmental Biology
- Franziska Biellmann, A. Hülsmeier, Dapeng Zhou, P. Cinelli, T. Hennet
- Medicine
- 2003
BMC Developmental Biology is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We do…
Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy.
- P. Thapa, Guodong Zhang, Dapeng Zhou
- Biology, ChemistryVaccine
- 26 May 2009
S1P1 receptor expression regulates emergence of NKT cells in peripheral tissues
- M. L. Allende, Dapeng Zhou, R. Proia
- BiologyThe FASEB Journal
- 1 January 2008
Results indicate that the S1P1 receptor expression on NKT cells is dispensable for development within thymus but is essential for the establishment of their tissue residency in the periphery.
A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells.
- Yang Liu, Randal D. Goff, P. Savage
- Biology, ChemistryJIM - Journal of Immunological Methods
- 2006
An alpha-galactosyl ceramide with improved solubility over KRN7000 is developed that effectively stains NKT cells, both mouse and human, and stimulates cytokine release at low concentrations.
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