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Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer

• Tianzhen Wang, Guang-Yu Wang, +4 authors Xiaobo Li
• Molecular Cancer
• 2015

RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-transcriptional regulators of gene expression, and their aberrant expression contributes to the development of… (More)

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.

• Jingbo Yan, Fang C. Mei, +12 authors Xiaodong Cheng
• Molecular and cellular biology
• 2013

The prototypic second messenger cyclic AMP (cAMP) is essential for controlling cellular metabolism, including glucose and lipid homeostasis. In mammals, the majority of cAMP functions are mediated by… (More)

Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy

• Jingjing Li, Dapeng Hao, +6 authors Li-jun Di
• Scientific Reports
• 2017

Epigenetic therapy is a novel tumor therapeutic method and refers to the targeting of the aberrant epigenetic modifications presumably at cancer-related genes by chemicals which are epigenetic… (More)

Integrated Analysis Reveals Tubal- and Ovarian-Originated Serous Ovarian Cancer and Predicts Differential Therapeutic Responses.

• Dapeng Hao, Jingjing Li, +4 authors Li-jun Di
• Clinical cancer research : an official journal of…
• 2017

Purpose: The relative importance of fallopian tube (FT) compared with ovarian surface epithelium (OSE) in the genesis of serous type of ovarian cancer (SOC) is still unsettled. Here, we followed an… (More)

An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer

• Xiang An, Yuanyuan Zhu, +15 authors Xiaobo Li
• Molecular therapy. Nucleic acids
• 2018

Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN) genes (STING) signaling is essential for antitumor immunity by inducing the production of type I IFN and thus… (More)

CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling

• Zhiqiang Zhao, Dapeng Hao, +8 authors Li-jun Di
• Oncogene
• 2018

Metastasis is the process through which the primary cancer cells spread beyond the primary tumor and disseminate to other organs. Most cancer patients die of metastatic disease. EMT is proposed to be… (More)

Immunogenomic Analyses of Advanced Serous Ovarian Cancer Reveal Immune Score is a Strong Prognostic Factor and an Indicator of Chemosensitivity.

• Dapeng Hao, Jie Liu, +5 authors Li-jun Di
• Clinical cancer research : an official journal of…
• 2018

Purpose: Ovarian cancer is one of the first human cancers for which in situ immune response was reported to be important for the clinical outcome. To elucidate the mechanistic relationship between… (More)

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