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The decoupling of producers and consumers in the publish/subscribe paradigm lends itself well to the support of mobile users who roam about the environment with intermittent network connectivity. This paper presents the first quantitative evaluation of publisher mobility in a distributed publish/subscribe system. Our results indicate that publisher mobility(More)
In this paper, some solution relationships between nonsmooth vector optimization problems and generalized vector variational-like inequalities are established under pseudoinvexity or invariant pseudomonotonicity. A perturbed generalized weak Stampacchia vector variational-like inequality problem and its relation with generalized weak Minty vector(More)
Hypothermia is an effective neuroprotective treatment for brain injury caused by intracerebral hemorrhage (ICH). It is reported to reduce brain edema and neuronal cell death. Thrombin, a coagulation protease released from blood clots, is critical in brain edema formation following ICH. Protease activated receptor‑1 (PAR‑1), matrix metalloproteinase‑9(More)
A series of chloro-pyridazine piperazines were developed based on the structure of human rhinovirus (HRV) capsid-binding inhibitors with proven activity using a pharmacophore model. A preliminary evaluation demonstrated potent activity against HRV-3 with low cytotoxicity. A docking analysis indicated that 8a could fit into, and form tight interactions(More)
A 72-year-old male with a history of prostate cancer and high prostate specific antigen levels underwent 99mtechnetium-methylene diphosphonate (99mTc-MDP) single-photon emission computed tomography/computed tomography (SPECT/CT), to identify bone metastasis. The patient possessed no previous history of serious illnesses or surgical procedures and no family(More)
STUDY OBJECTIVE The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia. DESIGN Prospective cohort study. SETTING Department of Anesthesiology, Jinling Hospital, Nanjing University,(More)