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Fuzzy c-means clustering (FCM) with spatial constraints (FCM_S) is an effective algorithm suitable for image segmentation. Its effectiveness contributes not only to the introduction of fuzziness for belongingness of each pixel but also to exploitation of spatial contextual information. Although the contextual information can raise its insensitivity to noise(More)
Effective and accurate diagnosis of Alzheimer's disease (AD), as well as its prodromal stage (i.e., mild cognitive impairment (MCI)), has attracted more and more attention recently. So far, multiple biomarkers have been shown to be sensitive to the diagnosis of AD and MCI, i.e., structural MR imaging (MRI) for brain atrophy measurement, functional imaging(More)
Different imaging modalities provide essential complementary information that can be used to enhance our understanding of brain disorders. This study focuses on integrating multiple imaging modalities to identify individuals at risk for mild cognitive impairment (MCI). MCI, often an early stage of Alzheimer's disease (AD), is difficult to diagnose due to(More)
At present, there are many methods for frontal view face recognition. However, few of them can work well when only one example image per class is available. In this paper, we present a new method based on SVD perturbation to deal with the 'one example image' problem and two generalized eigenface algorithms are proposed. In the first algorithm, the original(More)
Recently, a new technique called 2-dimensional principal component analysis (2DPCA) was proposed for face representation and recognition. The main idea behind 2DPCA is that it is based on 2D matrices as opposed to the standard PCA, which is based on 1D vectors. Although 2DPCA obtains higher recognition accuracy than PCA, a vital unresolved problem of 2DPCA(More)
The high-dimensional pattern classification methods, e.g., support vector machines (SVM), have been widely investigated for analysis of structural and functional brain images (such as magnetic resonance imaging (MRI)) to assist the diagnosis of Alzheimer's disease (AD) including its prodromal stage, i.e., mild cognitive impairment (MCI). Most existing(More)