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Fuzzy c-means clustering (FCM) with spatial constraints (FCM_S) is an effective algorithm suitable for image segmentation. Its effectiveness contributes not only to the introduction of fuzziness for belongingness of each pixel but also to exploitation of spatial contextual information. Although the contextual information can raise its insensitivity to noise(More)
Effective and accurate diagnosis of Alzheimer's disease (AD), as well as its prodromal stage (i.e., mild cognitive impairment (MCI)), has attracted more and more attention recently. So far, multiple biomarkers have been shown to be sensitive to the diagnosis of AD and MCI, i.e., structural MR imaging (MRI) for brain atrophy measurement, functional imaging(More)
At present, there are many methods for frontal view face recognition. However, few of them can work well when only one example image per class is available. In this paper, we present a new method based on SVD perturbation to deal with the 'one example image' problem and two generalized eigenface algorithms are proposed. In the first algorithm, the original(More)
Different imaging modalities provide essential complementary information that can be used to enhance our understanding of brain disorders. This study focuses on integrating multiple imaging modalities to identify individuals at risk for mild cognitive impairment (MCI). MCI, often an early stage of Alzheimer's disease (AD), is difficult to diagnose due to(More)
In this paper, a new feature extraction algorithm is developed based on canonical correlation analysis (CCA), called Local Discrimination CCA (LDCCA). The method considers a combination of local properties and discrimination between different classes. Not only the correlations between sample pairs but also the correlations between samples and their local(More)
In this paper, a novel subspace method called diagonal principal component analysis (DiaPCA) is proposed for face recognition. In contrast to standard PCA, DiaPCA directly seeks the optimal projective vectors from diagonal face images without image-to-vector transformation. While in contrast to 2DPCA, DiaPCA reserves the correlations between variations of(More)
Many machine learning and pattern classification methods have been applied to the diagnosis of Alzheimer's disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). Recently, rather than predicting categorical variables as in classification, several pattern regression methods have also been used to estimate continuous clinical variables(More)