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The major facilitator superfamily (MFS) is the largest family of secondary active transporters and is present in all life kingdoms. Detailed structural basis of the substrate transport and energy-coupling mechanisms of these proteins remain to be elucidated. YajR is a putative proton-driven MFS transporter found in many Gram-negative bacteria. Here we(More)
G-protein coupled receptors (GPCRs) play an essential role in eukaryotic cells signaling. According to phylogenetic analysis, most GPCRs belong to one of four classes, i.e. A, B, C, and Frizzled (Lagerstrom and Schioth, 2008). The class-C GPCR family contains metabotropic glutamate receptors (mGluR), γ-aminobutyric acid B receptors (GABA B receptor or GBR),(More)
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