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G-protein coupled receptors (GPCRs) play an essential role in eukaryotic cells signaling. According to phylogenetic analysis, most GPCRs belong to one of four classes, i.e. A, B, C, and Frizzled (Lagerstrom and Schioth, 2008). The class-C GPCR family contains metabotropic glutamate receptors (mGluR), γ-aminobutyric acid B receptors (GABA B receptor or GBR),… (More)