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Exo70 interacts with the Arp2/3 complex and regulates cell migration
TLDR
It is proposed that Exo70, in addition to functioning in exocytosis, also regulates actin at the leading edges of migrating cells, therefore coordinating cytoskeleton and membrane traffic during cell migration. Expand
Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3
TLDR
Salmonella Stealth Bomber Salmonella secretes a virulence factor, SipA, which helps it to invade epithelial cells of the gut, and during invasion, the host cell is triggered into synthesizing and secreting the apoptotic enzyme caspase-3, which diverts the host enzyme to its own use. Expand
The inflammation‐associated Salmonella SopA is a HECT‐like E3 ubiquitin ligase
TLDR
SopA, a Salmonella type III effector, mimics the mammalian HECT E3 ubiquitin ligase, and it is speculated that SopA ubiquitinate bacterial/host proteins involved inSalmonella‐induced intestinal inflammation. Expand
Recognition and Ubiquitination of Salmonella Type III Effector SopA by a Ubiquitin E3 Ligase, HsRMA1*
TLDR
The data suggest that efficient bacterial escape into the cytosol of epithelial cells requires HsRMA1-mediated SopA ubiquitination and contributes to Salmonella-induced enteropathogenicity. Expand
The C Terminus of SipC Binds and Bundles F-actin to Promote Salmonella Invasion
TLDR
It is demonstrated that amino acid residues 221–260 and 381–409 of full-length SipC were indispensable for its actin binding and bundling activities and Salmonella mutant strains lacking the actin bundling activity were less invasive into HeLa cells. Expand
Involvement of SipA in modulating actin dynamics during Salmonella invasion into cultured epithelial cells
TLDR
Results indicate that SipA is involved in modulating actin dynamics in cultured epithelial cells during Salmonella invasion. Expand
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase
TLDR
The crystal structure of SopA in two conformations suggests that SopA is a unique HECT E3 ligase evolved from the coevolutionary selective pressure at the bacterium-host interface. Expand
Inactivation of Bacillus anthracis spores in murine primary macrophages
TLDR
The data indicate that B.’anthracis spores germinate in and are subsequently killed by primary macrophages, suggesting effective killing of germinated spores and/or vegetative bacteria. Expand
Bacteria‐generated PtdIns(3)P Recruits VAMP8 to Facilitate Phagocytosis
TLDR
It is reported here that SopB‐generated PtdIns(3)P binds VAMP8/endobrevin to promote efficient bacterial phagocytosis and demonstrates that Salmonella exploit host SNARE proteins and vesicle trafficking to promote bacterial entry. Expand
Delineation and characterization of the actin nucleation and effector translocation activities of Salmonella SipC
TLDR
The delineation of the actin nucleation activity from the effector translocation activity of SipC is reported, showing that the central amino acid region (residues: 201–220) is essential for its actinucleation activity and the C‐terminal amino acids region is required for translocation of effectors. Expand
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