Daochun Sun

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Local structures of target mRNAs play a significant role in determining the efficacies of antisense oligonucleotides (ODNs), but some structure-based target site selection methods are limited by uncertainties in RNA secondary structure prediction. If all the predicted structures of a given mRNA within a certain energy limit could be used simultaneously,(More)
Sirt1, a conserved nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, has been implicated in modulating transcriptional silencing and cell survival, and seems to play a key role in carcinogenesis through deacetylation of important regulatory proteins. This makes it a potential target in cancer therapy. The purpose of this study was to(More)
Wnt/β-catenin pathway has critical roles in development and oncogenesis. Although significant progress has been made in understanding the downstream signaling cascade of this pathway, little is known regarding Wnt/β-catenin pathway modification of the cellular apoptosis. To identify potential genes regulated by Wnt/β-catenin pathway and involved in(More)
Antisense oligonucleotides (ODNs) technology is one of the important approaches for the sequence-specific knockdown of gene expression. ODNs have been used as research tools in the post-genome era, as well as new types of therapeutic agents. Since finding effective target sites within RNA is a hard work for antisense ODNs design, various experimental(More)
and Applied Analysis 3 radius δ ∈ 0, 1/2 . For φ, ε∗, ε 0 < ε∗ < ε, φ1 < φ − ε < φ − ε∗ < φ ε∗ < φ ε < φ2 , and R > R∗ > 2, we have ( q − 2)S(Ω(φ − ε∗, φ ε∗), R∗,W) n ( Ω ( φ − ε, φ ε), R, ̃ Rz ) q ∑ j 1 n ( Ω ( φ − ε, φ ε), R,W aj ) 256vπ24 lnR δ38 ε − ε∗ lnR − lnR∗ ( q − 2)S ( Ω ( φ − ε∗, φ ε∗, 1 R∗ ,W ))
Fluorescence in situ hybridization (FISH) continues to play an important role in clinical investigations. Laboratories may create their own cutoff, a percentage of positive nuclei to determine whether a specimen is positive or negative, to eliminate false positives that are created by signal overlap in most cases. In some cases, it is difficult to determine(More)
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