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Kentomonas gen. n., a new genus of endosymbiont-containing trypanosomatids of Strigomonadinae subfam. n.
This work describes the isolation, cultivation, as well as morphological and molecular characterization of a novel endosymbiont-harboring trypanosomatid species, Kentomonas sorsogonicus sp.
Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani
It is demonstrated that L. seymouri is well adapted for the environment of the warm-blooded host and remains a predominantly monoxenous species not capable of infecting vertebrate cells under normal conditions.
Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania
- Danyil Grybchuk, N. Akopyants, +17 authors V. Yurchenko
- Biology, MedicineProceedings of the National Academy of Sciences
- 28 December 2017
A broad survey of RNA viruses within trypanosomatids revealed several previously unidentified viral taxa including one designated “Leishbunyaviridae” and a highly divergent virus termed ”Leptomonas pyrrhocoris ostravirus 1”, which shed important insights on the emergence of viruses within an important trypanOSomatid clade relevant to human disease.
Molecular Characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan
These new virus-infected flagellates were isolated in the same region of Uzbekistan and the viral sequences differed by only nineteen SNPs, all except one being silent mutations, therefore, it is concluded that they belong to a single LRV2 species.
Molecular mechanisms of thermal resistance of the insect trypanosomatid Crithidia thermophila
Comparison with another thermoresistant monoxenous trypanosomatid, Leptomonas seymouri, revealed dramatic differences in transcription profiles of the two species with only few genes showing the same expression pattern, illustrating differences in the biology of these two parasites and distinct mechanisms of their thermotolerance.
RNA Viruses in Blechomonas (Trypanosomatidae) and Evolution of Leishmaniavirus
- Danyil Grybchuk, A. Kostygov, D. H. Macedo, J. Votýpka, J. Lukeš, V. Yurchenko
- Medicine, BiologymBio
- 16 October 2018
Evolution of leishmaniaviruses is more complex than previously thought and includes occasional host switching, and evidence that even representatives of the family Narnaviridae are capable of host switching and evidently have accomplished switches multiple times in the course of their evolution.
RNA viruses in trypanosomatid parasites: a historical overview
- Danyil Grybchuk, A. Kostygov, D. H. Macedo, C. M. d'Avila-Levy, V. Yurchenko
- Biology, MedicineMemorias do Instituto Oswaldo Cruz
- 19 February 2018
A historical overview of viruses of trypanosomatids is presented, starting with early reports of virus-like particles on electron microphotographs, and culminating in detailed molecular descriptions of viruses obtained using modern next generation sequencing-based techniques.
The First Non-LRV RNA Virus in Leishmania
The phylogenetic analyses suggest that LmarLBV1 originated from leishbunyaviruses of monoxenous trypanosomatids and, probably, is a result of genomic re-assortment.
Capsid Structure of Leishmania RNA Virus 1
- M. Procházková, Tibor Füzik, +5 authors P. Plevka
- Medicine, BiologyJournal of Virology
- 18 November 2020
It is shown that the LRV1 capsid contains positively charged clefts that may be sites for the cleavage of mRNAs of Leishmania cells, and enables the rational design of compounds targeting the putative decapping site.
Analyses of Leishmania-LRV Co-Phylogenetic Patterns and Evolutionary Variability of Viral Proteins
Leishmania spp. are important pathogens causing a vector-borne disease with a broad range of clinical manifestations from self-healing ulcers to the life-threatening visceral forms. Presence of…