Learn More
A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex.(More)
The objectives of this study are to establish the in vitro culture system for rat primary ameloblast and to investigate the effects of fluoride on cell viability, apoptosis, and ameloblastin (AMBN) secretion of primary rat ameloblast in vitro. Ameloblast was isolated from the tooth germ of the maxillomandibular molar and cultured in vitro. Cells were(More)
OBJECTIVE High fluoride can induce stress-mediated apoptosis and degradation of ameloblasts. Fas ligand (FasL) has been regarded as a key regulator in intracellular responses for stress-induced apoptosis in reproductive or cancerous cell lineages. The objective of this study is to explore the role of FasL in the regulation of ameloblast ultrastructure(More)
—Particle Swarm Optimization (PSO) has shown good search ability on many optimization problems. However, PSO easily suffers from local optima on some complex problems, such as multimodal function problems. This paper presents an improved PSO, namely IPSO, which employs an adaptive chaotic mutation operator. The adaptive mutation adjusts the step size of(More)
Target identification of bioactive compounds within the native cellular environment is important in biomedical research and drug discovery, but it has traditionally been carried out in vitro. Information about how such molecules interact with their endogenous targets (on and off) is currently highly limited. An ideal strategy would be one that recapitulates(More)
CONTEXT Iodine nutrition is a global event, especially for pregnant women. OBJECTIVE To develop applicable index of iodine intake for population during pregnancy. DESIGN, SETTING, AND PARTICIPANTS From 2012 to 2014, pregnant women at less than 8 weeks of gestation (n = 222) and reproductive-age women (n = 827) participated in this study. The pregnant(More)
Blood vessels normally maintain stereotyped lumen diameters and their stable structures are crucial for vascular function. However, very little is known about the molecular mechanisms controlling the maintenance of vessel diameters and the integrity of endothelial cells. We investigated this issue in zebrafish embryos by a chemical genetics approach. Small(More)
In this paper, a new cognitive radio (CR) scenario called Multiple Primary Transmit Power (MPTP) is investigated where the primary user (PU) could possibly work on more than one discrete transmit power levels. Different from most existing literatures where PU is assumed to operate with a constant transmit power only, this new consideration well matches the(More)