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A novel anticancer agent, icaritin, induced cell growth inhibition, G1 arrest and mitochondrial transmembrane potential drop in human prostate carcinoma PC-3 cells.
TLDR
A novel anticancer efficacy of icaritin mediated selectively via induction of cell cycle arrest but not associated with estrogen receptors in PC-3 cells is suggested. Expand
Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.
TLDR
It is found that cardiomyocyte differentiation was efficiently stimulated only if icariin was administrated between days 5 and 8 in differentiation course, which indicated with elevated percentage of embryoid bodies (EB) and with beating areas and up- regulated expression of alpha-actinin and troponin T. Expand
Reactive oxygen species involved in prenylflavonoids, icariin and icaritin, initiating cardiac differentiation of mouse embryonic stem cells
TLDR
The results revealed that the significant promoting effects of prenylflavonoids on cardiac differentiation was at least partly via ROS signaling cascades, and the facilitating abilities preferentially based on the nature of preNYlflav onoids themselves, but anti‐oxidative activity determined by the OH numbers and the positions in the structures do influence the cardiomyogenesis in vitro. Expand
Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines
TLDR
It is shown that hepatic premalignant alterations appeared in canines after a 10-day AAI oral administration, and it is suggested that anti-premalignant therapy may be crucial for preventing AAI-induced hepatocarcinogenesis. Expand
Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b
TLDR
The beneficial effects offered by MSC transplantation after myocardial infarction are at least partially because of improved autophagic flux through excreted exosome containing mainly miR-125b-5p. Expand
Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner.
TLDR
Enhanced co-expression of beta-tubulin III and choline acetyltransferase in neuronal differentiation from mouse ES cells is promoted by icaritin via estrogen receptor-independent action. Expand
Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis.
TLDR
It is suggested that Ginsenoside Rg1 protected against Aβ25-35-induced apoptosis at least in part by two complementary GR-dependent ERK phosphorylation pathways: down-regulating HIF-1α initiated protein nitrotyrosination, and inhibiting mitochondrial apoptotic cascades. Expand
Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3
TLDR
Cardiac-specific tamoxifen-inducible NDUFA13 knockout mice are generated and it is demonstrated that cardiac-specific heterozygous knockout mice exhibited normal cardiac morphology and function in the basal state but were more resistant to apoptosis when exposed to ischemia-reperfusion (I/R) injury. Expand
Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro
TLDR
Icariin facilitated the directional differentiation of ES cells into cardiomyocytes at a concentration of 1×10−7 mol/L and was related to increasing and accelerating gene expression of α-cardiac MHC and MLC-2v in EBs in the early cardiac developmental stage. Expand
Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro
TLDR
The inducible effects of icariin were partly related to increase in the expression of cardiac developmental-dependent genes, and elevation of the cAMP/cGMP ratio in ES cells, as well as upregulation of endogenous NO generation during the early stages of cardiac development. Expand
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