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Hedgehog signalling in the mouse requires intraflagellar transport proteins
Intraflagellar transport (IFT) proteins were first identified as essential factors for the growth and maintenance of flagella in the single-celled alga Chlamydomonas reinhardtii. In a screen forExpand
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Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
Reprogramming of mouse and human somatic cells can be achieved by ectopic expression of transcription factors, but with low efficiencies. We report that DNA methyltransferase and histone deacetylaseExpand
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Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
Ectopic expression of defined sets of genetic factors can reprogram somatic cells to induced pluripotent stem (iPS) cells that closely resemble embryonic stem (ES) cells. The low efficiency withExpand
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A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.
The combined activity of three transcription factors can reprogram adult cells into induced pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering reprogramming factorsExpand
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Cilia and Hedgehog responsiveness in the mouse.
The intraflagellar transport (IFT) proteins Ift172/Wimple and Polaris/Ift88 and the anterograde IFT motor kinesin-II are required for the production and maintenance of cilia. These proteins are alsoExpand
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An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells.
Human pluripotent stem cells (hPSCs) offer a unique platform for elucidating the genes and molecular pathways that underlie complex traits and diseases. To realize this promise, methods for rapid andExpand
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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily conserved, recent studies indicate that fundamental differences exist between Drosophila and vertebrates in the wayExpand
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Mouse Dispatched homolog1 Is Required for Long-Range, but Not Juxtacrine, Hh Signaling
Precise patterning of cell types along the dorsal-ventral axis of the spinal cord is essential to establish functional neural circuits. In order to prove the feasibility of studying a singleExpand
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TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells
TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which can lead to DNA demethylation. However, direct connections between TET-mediated DNA demethylation andExpand
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