Danuta Palut

Learn More
The effect of permethrin on relative liver weight (RLW) and the activity of hepatic monooxygenase system related to cytochrome P-4502B and 2A was studies. The effect of permethrin was compared with DDT used as phenobarbital-type of monooxygenase inducer (induces cyt. P-4502B). Male Wistar rats received permethrin and DDT for 4 days at 24 h intervals in(More)
The aim of the present studies was to describe the effect of two organohalogen pesticides: DDT and bromopropylate, on early changes in rat liver, proposed in the literature to be useful endpoints in screening of non-genotoxic hepatocarcinogens and/or liver tumor promoters. We investigated the effects on the following endpoints: hepatomegaly, mitogenesis(More)
In this study permethrin [(3-phenoxyphenyl)-methyl-3-(2,2-dichloroethenyl)-2,2-dim ethylcyclopropanecarboxylate] and DDT [1,1-(2,2,2 trichloroethylidene)-bis-(4-chlorobenzene)] were compared in rats for their effects on early hepatic changes, proposed in the literature to be useful endpoints in screening for non-genotoxic hepatocarcinogenesis and/or liver(More)
A study was performed to determine whether diclofop (2-(4-(2,4-dichlorophenoxy) phenoxy)propionic acid), introduced as a herbicide, exhibits the properties of peroxisome proliferators (PPs). Diclofop was administered orally at 7-56 mg/kg body weight per day to male Wistar rats for 2, 4, 7 or 14 consecutive days and some effects regarded as early hepatic(More)
Fenarimol administered in one single oral dose of 125 or 62.5 mg kg-1 body wt. day-1, respectively, stimulated rat liver enlargement at a dose-independent rate. Three single doses of fenarimol produced dose-dependent liver growth, whereas five single doses caused no further increase in liver weight. This increase was accompanied by an increase in hepatic(More)
It is commonly believed that in short-term tests hepatic cytochrome P-450b inducers stimulate liver enlargement and mitogenesis in the absence of overt hepatotoxic effects. In this investigation male Wistar rats received naurimol (an organochlorine pesticide) in one, three and five oral doses of 31.5, 62.5 and 125 mg kg-body wt. day-, whereupon the effects(More)
This review summarizes recent findings indicating that members of the orphan nuclear receptor superfamily regulate the synthesis of their CYP genes which code CYP enzymes involved in metabolism of endogenous and exogenous compounds. The foreign compounds metabolism and the role played by individual cytochrome P450 (CYP) enzymes in the activation and(More)
Peroxisome proliferators are diverse group of chemicals which are regarded as rodent hepatocarcinogens and/or- liver tumor promoters. These compounds when administered to rats and mice produce a dramatic increase in the size and number of hepatic peroxisomes and increase in activities of enzymes involved in beta-oxidation of fatty acids. Peroxisome(More)
The study aimed at the evaluation of total mercury content in hair and urine of the workers occupationally exposed to various levels of mercury vapours. The hair and urine were taken from the workers employed in Chemical Plant Oświecim and from thermometer factory in Warsaw. The urine and hair of non-exposed Warsaw inhabitants served as a reference. Mercury(More)