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DNA repair capacity (DRC) can be altered based on sequence variations in DNA repair genes, which may result in cancer susceptibility. The current study was to evaluate the association between genetic polymorphisms, including associated haplotypes of xeroderma pigmentosum complementary group D (XPD), and individual susceptibility to gastric cancer.(More)
T cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) could weaken the Th1-mediated anti-tumor responses and accelerate the tumor cell proliferation by inhabiting the production of IL-2 or IFN-γ. This study was to assess the association between TIM-3 genetic variations and the development of gastric cancer. Five polymorphisms located in the(More)
Poria cocos F.A.Wolf is a Chinese traditional medicine used to treat chronic gastritis, edema, nephrosis, gastric atony, and acute gastroenteric catarrh. Polysaccharides are the main active component of P. cocos. We obtained polysaccharides PCP-1, PCP-2, and PCP-3 from the degradation of P. cocos polysaccharides (PCP) with different concentrations of H2O2(More)
Peliglitazar, a PPAR α/γ agonist, was found to undergo acid as well as base catalyzed degradation. The acid catalyzed degradation led to the formation of benzylic alcohol and glycine carbamate and the base catalyzed degradation led to formation of p-hydroxyanisole and an amine degradant. In capsule formulations, the capsules with the lowest drug-loading(More)
Response surface method (RSM) was employed to optimize the extraction conditions of polysaccharides from Rhizoma Panacis Majoris (the rhizomes of Panax japonicus C. A. Mey. var. major (Burk.) C. Y. Wu et K. M. Feng) (RPMP), a well-known Chinese traditional medicine. In order to obtain the optimal processing parameters, a three-variable Box-Behnken designs(More)
An all-silicon passive optical diode based on optical nonlinearity in cascaded photonic crystal (PhC) L3 cavities is proposed and demonstrated. A nonreciprocal transmission ratio (NTR) of 30.8 dB and insertion loss of 8.3 dB are realized in the device. The device has a relatively broad 17 dB operation bandwidth of 0.08 nm, and at least 16 dB of NTR is(More)
A silicon light emitter in telecom-band based on a single germanium quantum dot precisely embedded in a silicon photonic crystal nanocavity is fabricated by a scalable method. A sharp resonant luminescence peak is observed at 1498.8 nm, which is enhanced by more than three orders of magnitude. The Purcell factor for the fundamental resonant mode is(More)
A design for enhancing the quality (Q) factor of a photonic crystal ring resonator (PCRR) is introduced. The highest Q factor based on simulations is 121,000. The analysis of momentum space distributions of the electric field profile for PCRR resonance shows that a high Q factor of a PCRR is attributed to the reduction of tangential k-vector component(More)
Development of 0.1, 0.5, and 1.0 mg entecavir tablet formulations for the treatment of hepatitis B virus was challenging for content uniformity. Entecavir with pKa of 2.8 and 9.8 does not have sufficient solubility in acidic or alkaline medium or in common pharmaceutical solvents such as ethanol to dissolve the drug in granulating fluid to prepare the(More)
Light emitter based on Ge quantum dots embedded in photonic crystal ring resonator is designed and fabricated. Six sharp resonant peaks dominate the photoluminescence (PL) spectrum ranging from 1500 to 1600 nm at room temperature. The light emission enhancement is due to Purcell effect and high collection efficiency of the PCRR verified by calculated(More)