Danny Yuxing Huang

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Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary tangles of Alzheimer disease. Late-onset familial and sporadic Alzheimer disease patients have an increased frequency of one of the three common apoE alleles, epsilon 4,(More)
Software defined networks (SDNs) depart from traditional network architectures by explicitly allowing third-party software access to the network's control plane. Thus, SDN protocols such as OpenFlow give network operators the ability to innovate by authoring or buying network controller software independent of the hardware. However, this split design can(More)
Apolipoprotein E (APOE) genotype and advancing aging are interacting ri sk factors in the expression of late onset and sporadic Alzheimer's Disease (AD). We tested the hypothesis that 2 products of lipid peroxidation, malondialdehyde (MDA) and 4 hydroxy-2-nonenal (HNE), covalently modify APOE and alter its metabolism. In vitro, both HNE and MDA crosslinked(More)
The extracellular matrix protein laminin profoundly affects neuronal adhesion, spreading, differentiation, and growth by binding integrin-type cell surface receptors. Laminin binds other basement membrane components, including heparan sulfate proteoglycans. Apolipoprotein E (apoE) also binds basement membrane and heparan sulfate proteoglycans and(More)
In this paper, we present an empirical study of a recent spam campaign (a “stress test”) that resulted in a DoS attack on Bitcoin. The goal of our investigation being to understand the methods spammers used and impact on Bitcoin users. To this end, we used a clustering based method to detect spam transactions. We then validate the clustering results and(More)
The risk of Alzheimer's disease is determined, in part, by inheritance of specific alleles of ApoE. Isoform specific interactions of ApoE have been shown with the microtubule-associated protein tau, which forms the neurofibrillary tangle in this disease. Synthetic peptides representing each of the four microtubule-binding domains of tau more avidly bind(More)
The apolipoprotein E type 4 allele is a susceptibility gene for late-onset Alzheimer's disease. Apolipoprotein E is found in neurons, some of which contain paired helical filaments made of the microtubule-associated protein tau. Previous studies have demonstrated that the apoE3 isoform, but not the apoE4 isoform, binds tau with high avidity. Because the(More)
Internet crime has become increasingly dependent on the underground economy: a loose federation of specialists selling capabilities, services, and resources explicitly tailored to the abuse ecosystem. Through these emerging markets, modern criminal entrepreneurs piece together dozens of à la carte components into entirely new criminal endeavors. From an(More)
At the current stratospheric value of Bitcoin, miners with access to significant computational horsepower are literally printing money. For example, the first operator of a USD $1,500 custom ASIC mining platform claims to have recouped his investment in less than three weeks in early February 2013, and the value of a bitcoin has more than tripled since(More)