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Pituitary adenylyl cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two closely related neuropeptides exhibiting overlapping activities which have actions on almost every organ system of the body. To determine if these peptides exert essential but redundant functions, we interbred VIP- and PACAP-deficient mice to obtain(More)
UNLABELLED Awareness of cancer therapy-induced toxicities is important for all clinicians treating patients with cancer. Cancer therapy has evolved to include classic cytotoxic agents in addition to newer options such as targeted agents and catheter-directed chemoembolisation. Several adverse affects can result from the wide array of treatments including(More)
PA-GOSUB (Proteome Analyst: Gene Ontology Molecular Function and Subcellular Localization) is a publicly available, web-based, searchable and downloadable database that contains the sequences, predicted GO molecular functions and predicted subcellular localizations of more than 107,000 proteins from 10 model organisms (and growing), covering the major(More)
— Researchers often have access to a variety of different high-performance computer (HPC) systems in different administrative domains, possibly across a wide-area network. Consequently, the security infrastructure becomes an important component of an overlay metacomputer: a user-level aggregation of HPC systems. The Grid Security Infrastructure (GSI) uses a(More)
Researchers often have non-privileged access to a variety of high-performance computer (HPC) systems in different administrative domains, possibly across a wide-area network. 1 Consequently, the security infrastructure becomes an important component of an overlay metacomputer: a user-level aggregation of HPC systems. The Trellis Security Infrastructure(More)
PA-GOSUB (Proteome Analyst: GO Molecular Function and Subcellular Localization) is a publicly-available, web-based, searchable, and downloadable database that contains the sequences, predicted GO molecular functions, and predicted subcellular localizations of the more than 107,000 proteins from 10 model organisms (and growing), covering the major kingdoms(More)
The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission. The undersigned certify that they have(More)
CD4+ (T helper) lymphocytes appear to play important roles in neuron survival and regeneration after injury, although their functions in regulating gene expression in injured neurons are unknown. Mice with targeted mutations in the STAT4 and STAT6 genes are deficient in T helper (Th)1 and Th2 responses, respectively, and have been used to determine the(More)
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