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BACKGROUND Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both(More)
BACKGROUND Postmortem and in vivo imaging data support the hypothesis that premature myelin breakdown and subsequent homeostatic remyelination attempts with increased oligodendrocyte and iron levels may contribute to Huntington's Disease (HD) pathogenesis and the symmetrical progress of neuronal loss from earlier-myelinating striatum to later-myelinating(More)
BACKGROUND Age-related myelin breakdown is most evident in later-myelinating white matter (LMwm) brain regions. This process might degrade cognitive processing speed (CPS) underlying age-related cognitive decline and the predominance of age as a risk factor for Alzheimer's disease (AD). Apolipoprotein E (ApoE) 4 allele is the second most important AD risk(More)
Researchers who develop new home technologies using connected devices often want to conduct large-scale field studies in homes to evaluate their technology, but conducting such studies today is extremely challenging. Inspired by the success of PlanetLab, which enabled development and evaluation of global network services, we are developing a shared(More)
We propose a novel geometric skinning approach that unifies geometric blending for rigid-body models with embedded surfaces for finite-element models. The resulting skinning method provides flexibility for modelers and animators to select the desired dynamic degrees-of-freedom through a combination of coupled rigid and deformable structures connected to a(More)
Integrating sensor systems within the home can be a tedious process due to the challenges of deploying systems across multiple environments, customizing applications, and connecting across various devices. We demonstrate the deployment of sensors using the Lab of Things platform within a residence over a 3 month period. We developed a real time(More)
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