Danny Guerra

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AIM High-density lipoproteins (HDLs) have several potentially protective vascular effects. Most clinical studies of therapies targeting HDL have failed to show benefits vs. placebo. OBJECTIVE To investigate the effects of an HDL-mimetic agent on atherosclerosis by intravascular ultrasonography (IVUS) and quantitative coronary angiography (QCA). DESIGN(More)
We tested the hypothesis that the level of the DNA repair protein O6-alkylguanine-DNA alkyltransferase in brain tumors was correlated with resistance to carmustine (BCNU) chemotherapy. Alkyltransferase levels in individual cells in sections from 167 primary brain tumors treated with BCNU were quantitated with an immunofluorescence assay using monoclonal(More)
O6-methylguanine-DNA methyltransferase (MGMT) activity was measured in 68 tissue samples taken from brain. A wide range in activity among samples was observed, with all nonmalignant samples showing transferase activity (Mer+) but approximately 15% of WHO grade II low-grade astrocytomas and WHO grade IV glioblastoma multiformes lacking activity (Mer-). On(More)
BACKGROUND Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduction in ischemic cardiomyopathy. (More)
Gastric volvulus in children might be observed both as an acute form, characterized by gastric necrosis with sudden perforation and patient's death and as an idiopathic or chronic form with a less severe insurgence that causes epigastric pain, vomit and gastric distension. The latter could resolve spontaneously but recurs frequently. The acute form rises in(More)
UNLABELLED We report a series of patients with postextubation pulmonary edema who had no obvious risk factors for the development of this syndrome. METHODS Patients identified by the pulmonary consultation service at an academic medical center were reviewed. RESULTS Fourteen cases were collected and analyzed. The average age was 34.5 years; 12 patients(More)
e21030 Background: The process of bone metastasization includes numerous steps such as proliferation, invasion and adhesion, involving molecules, growth factors, chemochines and their receptors that confer the bone-like phenotype. Thus, only cancer cells with specific features will be able to reach and colonize bone tissue. The early prediction of relapse(More)
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