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The Properties of Adaptive Walks in Evolving Populations of Fungus
A novel method to infer the number and fitness effect of beneficial mutations reveals that the bulk of adaptive evolution is attributable to a few mutations with variable effects on fitness.
Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria
TLDR
A role for multicopy plasmids as catalysts for the evolution of antibiotic resistance in bacteria is uncovered, and it is found that the plasmid accelerated resistance evolution by increasing the rate of appearance of novel TEM-1 mutations, thereby conferring resistance to ceftazidime. Expand
Divergent evolution peaks under intermediate population bottlenecks during bacterial experimental evolution
TLDR
The hypothesis that bottleneck intensity shapes parallel evolution is tested by elucidating the genomic basis of adaptation to antibiotic-supplemented media in hundreds of populations of the bacterium Pseudomonas fluorescens Pf0-1, demonstrating that population bottlenecking can be a major predictor of parallel evolution, but precisely how is more complex than many simple theoretical predictions. Expand
THE LENGTH OF ADAPTIVE WALKS IS INSENSITIVE TO STARTING FITNESS IN ASPERGILLUS NIDULANS
TLDR
The results suggest that the length of adaptive walks may be independent of the fitness of the founding genotype and, moreover, that poorly adapted populations can quickly adapt to novel environments. Expand
Spontaneous mutation rate is a plastic trait associated with population density across domains of life
TLDR
It is determined that there is indeed density-associated mutation-rate plasticity (DAMP) at multiple loci in both eukaryotes and bacteria, with up to 23-fold lower mutation rates at higher population densities, and that the degree of plasticity varies, even among closely related organisms. Expand
Parasite diversity drives rapid host dynamics and evolution of resistance in a bacteria‐phage system
TLDR
It is demonstrated that parasite diversity has rapid effects on host–parasite population dynamics and evolution by selecting for different resistance mutations and affecting the magnitude of bacterial suppression and recovery. Expand
Environmental variation alters the fitness effects of rifampicin resistance mutations in Pseudomonas aeruginosa
TLDR
The results highlight the need to consider environmental heterogeneity and genotype‐by‐environment interactions for fitness in models of resistance evolution and suggest that environmental heterogeneity may influence whether the costs of resistance are likely to be ameliorated by second‐site compensatory mutations or by reversion to wild‐type rpoB. Expand
Modelling colony population growth in the filamentous fungus Aspergillus nidulans.
TLDR
A mechanistic model based on physiological parameters that influence colony growth, namely mycelial growth rate and sporulation rate, is presented as an exemplar of models for other filamentous fungi to predict the number of individual nuclei present in a colony through time. Expand
Epistatic interactions between ancestral genotype and beneficial mutations shape evolvability in Pseudomonas aeruginosa
TLDR
The results suggest that the role of magnitude epistasis in constraining evolvability may be underappreciated and is likely to be greatest under the biologically relevant mutation supply rates that make back mutations probabilistically unlikely. Expand
Identifying and exploiting genes that potentiate the evolution of antibiotic resistance
TLDR
The ability to evolve resistance to the antibiotic ceftazidime is shown to vary across the Pseudomonas genus because the AmpR global transcriptional regulator potentiates evolution and blocking this pathway can eliminate pathogenic strains before they evolve resistance. Expand
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