Danilo Machado

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BACKGROUND Deep brain stimulation (DBS) is being investigated as a treatment for major depression, but its mechanisms of action are still unknown. We have studied the effects of ventromedial prefrontal cortex (vmPFC) stimulation in a chronic model of depression and assessed the involvement of the serotonergic system and brain derived neurotrophic factor(More)
While considerable clinical evidence implicates thyroid hormones (THs) in depressive illness, the specific nature of this involvement remains unclear. The alpha1 subtype (TR-alpha1) is the most abundant TH receptor in brain. Here we investigated changes in TR-alpha1 mRNA in the chronic mild stress (CMS) model of depression. Rats were exposed to a CMS(More)
The relevance of automatically identifying rhetorical moves in scientific texts has been widely acknowledged in the literature. This study focuses on abstracts of standard research papers written in English and aims to tackle a fundamental limitation of current machine-learning classifiers: they are mono-labeled, that is, a sentence can only be assigned one(More)
BACKGROUND Evidence on the diagnostic performance of palpatory methods and possible confounding factors is scarce. OBJECTIVES To examine the sensitivity of palpatory methods for location of lumbopelvic landmarks and to assess its association with personal characteristics. METHODS Eighty-three participants (41 men, 55.6 (16.5) years, 25.9 (4.8) kg/m2(More)
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