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Drug absorption, sufficient and reproducible bioavailability and/or pharmacokinetic profile in humans are recognized today as one of the major challenges in oral delivery of new drug substances. The issue arose especially when drug discovery and medicinal chemistry moved from wet chemistry to combinatorial chemistry and high throughput screening in the(More)
We present an efficient algorithm for vessel segmentation of digital subtraction angiography (DSA) images. Continuous DSA images (projections), obtained by X-ray fluoroscopy with contrast-media, are normally used as road maps in vessel catheterization. A more efficient technique would consist in the use of a 3D model reconstruction of the vascular tree,(More)
In U-shaped, hand-size magnetic resonance surface scanners, imaging is performed along only one spatial direction, with the application of just one gradient (one-dimensional imaging). Lateral spatial resolution can be obtained by magnet displacement, but, in this case, resolution is very poor (on the order of some millimeters) and cannot be useful for(More)
Vascular catheterization is a common procedure in clinical medicine. It is normally performed by a specialist using an X-ray fluoroscopic guide and contrast-media. In the present paper, an image-guided navigation system which indicates a path providing guidance to the desired target inside the vascular tree is described with the aim of reducing the exposure(More)
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