Danijela Domazet-Damjanov

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A water-soluble formulation of CoQ10 (WS-CoQ10) was shown to stabilize mitochondria and prevent oxidative stress-induced neuronal death. Presenilin-1 (PS-1)-mutated Alzheimer's Disease (AD) fibroblasts (PSAF) were used for studying the effects of PS-1 mutation. PS-1 mutation correlated to increased reactive oxygen species (ROS) production and stress induced(More)
In response to external oxidative stress/DNA damaging agents, mammalian cells may choose one of the following pathways to avoid propagation of the damaged cells: repair the DNA and proceed with the normal cell cycle; trigger apoptosis; or undergo senescence to block cell division. If these safeguard mechanisms fail, cells containing damaged/mutated DNA will(More)
Neuronal cells are exclusively dependent on oxidative phosphorylation for energy and are under constant threat of oxidative damage due to mitochondrial production of reactive oxygen species by partial reduction of molecular oxygen. These cells also have a multitude of antioxidative defense mechanisms, but there is a slow decline of antioxidative defence(More)
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