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Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility
Why do some individuals succumb to stress and develop debilitating psychiatric disorders, whereas others adapt well in the face of adversity? There is a gap in understanding the neural bases ofExpand
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Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: Implications for treatment resistance
Significance Responsiveness, resistance to, and speed of treatment are major problems for depression. The energetic and epigenetic agent acetyl-l-carnitine (LAC) is known to exert rapidExpand
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Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity
Significance Chronic stress alters the hippocampal responses to familiar and novel stressors, behaviorally, physiologically, and epigenetically. In the aftermath of chronic stress in WT mice and inExpand
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Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress
We demonstrate that stress differentially regulates glutamate homeostasis in the dorsal and ventral hippocampus and identify a role for the astroglial xCT in ventral dentate gyrus (vDG) in stress andExpand
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Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant
The adult brain is capable of adapting to internal and external stressors by undergoing structural plasticity, and failure to be resilient and preserve normal structure and function is likely toExpand
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ACNP 57th Annual Meeting: Poster Session I
Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.Individual contributor disclosures may be found within the abstracts. Asterisks in the author lists indicate presenterExpand