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Cannabinoid pharmacology has proven nettlesome with issues of promiscuity a common theme among both agonists and antagonists. One recourse is to develop allosteric ligands to modulate cannabinoid… Continue Reading
2-Arachidonoylglycerol (2-AG) is the most abundant endogenous cannabinoid in the brain and an agonist at two cannabinoid receptors (CB1 and CB2). The synthesis, degradation and signaling of 2-AG have… Continue Reading
Graphical abstract Figure. No caption available. &NA; The cannabinoid signaling system is found throughout the CNS and its involvement in several pathological processes makes it an attractive… Continue Reading