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Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

• Cindy S Ma, S anee Suryani, +5 authors Stuart G Tangye
• Immunology and cell biology
• 2009

T follicular helper (T(FH)) cells are a specialized subset of CD4(+) T cells that localize to B-cell follicles, where they are positioned to provide help for the induction of optimal humoral immune… (More)

Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

• Vanessa L. Bryant, Cindy S Ma, +5 authors Stuart G Tangye
• Journal of immunology
• 2007

Differentiation of B cells into Ig-secreting cells (ISC) is critical for the generation of protective humoral immune responses. Because of the important role played by secreted Ig in host protection… (More)

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

• Carrie L Lucas, Hye Sun Kuehn, +25 authors Gulbu Uzel
• Nature Immunology
• 2014

The p110δ subunit of phosphatidylinositol-3-OH kinase (PI(3)K) is selectively expressed in leukocytes and is critical for lymphocyte biology. Here we report fourteen patients from seven families who… (More)

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses.

• Nina Chevalier, David Jarrossay, +6 authors Charles R Mackay
• Journal of immunology
• 2011

High expression of CXCR5 is one of the defining hallmarks of T follicular helper cells (T(FH)), a CD4 Th cell subset that promotes germinal center reactions and the selection and affinity maturation… (More)

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

• Danielle T Avery, Elissa K Deenick, +26 authors Stuart G Tangye
• The Journal of experimental medicine
• 2010

Engagement of cytokine receptors by specific ligands activate Janus kinase-signal transducer and activator of transcription (STAT) signaling pathways. The exact roles of STATs in human lymphocyte… (More)

Resting human memory B cells are intrinsically programmed for enhanced survival and responsiveness to diverse stimuli compared to naive B cells.

• Kim L. Good, Danielle T Avery, Stuart G Tangye
• Journal of immunology
• 2009

Enhanced secondary Ab responses are a vital component of adaptive immunity, yet little is understood about the intrinsic and extrinsic regulators of naive and memory B cells that result in… (More)

BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.

• Danielle T Avery, Susan L. Kalled, +7 authors Stuart G Tangye
• The Journal of clinical investigation
• 2003

The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must be strictly… (More)

Intrinsic differences in the proliferation of naive and memory human B cells as a mechanism for enhanced secondary immune responses.

• Stuart G Tangye, Danielle T Avery, Elissa K Deenick, Philip D. Hodgkin
• Journal of immunology
• 2003

Humoral immune responses elicited after secondary exposure to immunizing Ag are characterized by robust and elevated reactivity of memory B cells that exceed those of naive B cells during the primary… (More)

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

• Cindy S Ma, Danielle T Avery, +22 authors Stuart G Tangye
• Blood
• 2012

T follicular helper (Tfh) cells are critical for providing the necessary signals to induce differentiation of B cells into memory and Ab-secreting cells. Accordingly, it is important to identify the… (More)

Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity.

• Amanda K. Cuss, Danielle T Avery, +4 authors Stuart G Tangye
• Journal of immunology
• 2006

X-linked lymphoproliferative disease (XLP) is a severe immunodeficiency associated with a marked reduction in circulating memory B cells. Our investigation of the B cell compartment of XLP patients… (More)

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