Danielle Port

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PURPOSE To determine the prevalence and type of BRCA1 and BRCA2 (BRCA) mutations among Hispanics in the Southwestern United States and their potential impact on genetic cancer risk assessment (GCRA). PATIENTS AND METHODS Hispanics (n = 746) with a personal or family history of breast and/or ovarian cancer were enrolled in an institutional review(More)
Effective risk reduction strategies can be derived mechanically given sufficient characterization of the risks present in the system and the effectiveness of available risk reduction techniques. Quantitative assessments of risks and risk reduction techniques are likely to be inaccurate. In this paper we describe sensitivity analysis experiments which we(More)
The haemodynamic effects of equi-anaesthetic doses of alphaprodine and sulfentanil were evaluated in mongrel dogs ventilated mechanically. The effects of the addition of atropine were assessed for each drug, as were the effects of breathing nitrous oxide 60 per cent with oxygen and nitrogen 60 per cent with oxygen and the administration of naloxone. The(More)
1514 Background: Little is known about prevalence or ancestral origins of BRCA1and BRCA2 (BRCA) mutations among high-risk Hispanics, the fastest growing relatively underserved population in the U.S. METHODS Individuals of self-reported Hispanic origin with a personal or family history of breast and/or ovarian cancer were enrolled in an IRB-approved(More)
The cardiovascular effects of two intravenous rates of butorphanol infusion (0.1 and 0.2 mg/kg/min) were measured in 32 dogs breathing oxygen and nitrous oxide in oxygen. Sixteen dogs were premedicated with atropine and the other 16 were unpremedicated. Of the dogs receiving the higher dose infusion rate, 25% moved with a tail-clamp stimulus whereas 75%(More)
The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder mutation in Jewish mutation carriers that arose before the dispersion of Jews in the Diaspora ∼2500 years ago. The aim of this study was to assess the haplotype in ethnically diverse(More)
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