Danielle O'Neill

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Thirty-three children ranging from 2 weeks to 12 years of age were selected for allopurinol loading, 16 on the basis of an increased urinary orotate excretion detected by routine organic acid analysis (group A), and 17 for clinical reasons suggesting a urea cycle defect (group B). The allopurinol load test proved positive in 13 of 16 patients from group A,(More)
Fifty patients ranging in age between 50-78 years (mean, 56) underwent surgery for a herniated lumbar disc between January 1986 and July 1988. All had objective clinical and radiographic evidence of a herniated disc. All had had failure during an appropriate period of conservative treatment. Far lateral herniation occurred in 8%, and 28% had disc(More)
Eighty-one patients who had spinal fusions performed for back pain over a 7-year period were reviewed; 74% were satisfied with the outcome of their surgery, mainly because of the degree of pain relief obtained. Based on lateral radiographs of the fusion area in flexion and extension, there was a 34% pseudarthrosis rate in first-time fusions. However, there(More)
In a prospective study we identified a group of 12 patients diagnosed as having acute myocardial infarction but with electrocardiographic features of non-transmural infarction and serological evidence of recent Coxsackie B infection favouring the possibility of myocarditis. The group included 9 females and 3 males, aged from 38-60 y. Coronary arteriography(More)
Although the pathogenesis of primary pulmonary hypertension remains obscure, it has long been established that exposure to the hypoxic stimulus of high altitude produces an increase in pulmonary arterial pressure in man and this increase may well be completely reversible.' 2 The characteristic vascular changes of primary pulmonary hypertension are rarely(More)
OBJECTIVE To test a proposed mechanism for the effect of balance-based torso-weighting (BBTW) in people with multiple sclerosis (MS) and healthy controls. The mechanism to be tested is that application of light weights to the trunk may result in a biomechanical shift of postural sway in the direction of weighting, mechanically facilitating maintenance of(More)
It has been suggested that Coxsackie B virus infections may play a part in causing or triggering myocardial infarction. This study was designed to compare the incidence of such infections in Coronary Care Unit patients and normal controls. The choice of a suitable criterion for diagnosis of Coxsackie infection is discussed fully. Two hundred and fifty(More)
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