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Control of Vascular Smooth Muscle Cell Growth by Connexin 43
Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellularExpand
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Soluble guanylyl cyclase-activated cyclic GMP-dependent protein kinase inhibits arterial smooth muscle cell migration independent of VASP-serine 239 phosphorylation.
Coronary artery disease (CAD) accounts for over half of all cardiovascular disease-related deaths. Uncontrolled arterial smooth muscle (ASM) cell migration is a major component of CAD pathogenesisExpand
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The Soluble Guanylate Cyclase Stimulator BAY 41-2272 Inhibits Vascular Smooth Muscle Growth through the cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase Pathways
Vascular smooth muscle (VSM) proliferation and migration are key components in vessel remodeling. Cyclic nucleotide signaling is protective and has long-served as a therapeutic target againstExpand
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Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells
BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanismsExpand
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Multiple Kinase Involvement in the Regulation of Vascular Growth
The initial discovery of protein phosphorylation as a regulatory mechanism for the control of glycogen metabolism has led to intense interest of protein phosphorylation in regulating protein functionExpand
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Exchange protein activated by cAMP (EPAC) controls migration of vascular smooth muscle cells in concentration and time-dependent manner
Abstract Background: Cyclic AMP influences many facets of signaling in vascular smooth muscle cells (VSMCs) including those mediated by protein kinase A (PKA) and those operating through exchangeExpand
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Abstract 297: Cyclic GMP Reduces Vascular Smooth Muscle Migration through Inhibition of TGF-ß1/Smad Signaling
Abnormal vascular smooth muscle (VSM) growth remains an elemental foundation of vasculoproliferative disorders including atherosclerosis and restenosis. Many second messenger, cytokine, and growthExpand
BAY 41-2272 inhibits PDE activity in rat primary VSMCs
BAY 41-2272 (BAY) is a potent stimulator of soluble guanylyl cyclase (sGC); however, its mechanism of action is not well defined. We previously demonstrated in rat A7R5 vascular smooth muscle cellsExpand