Danielle M Kerkovich

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Cerebral palsy (CP) is defined as motor impairment that limits activity, and is attributed to non-progressive disturbances during brain development in fetuses or infants. The motor disorders of CP are frequently accompanied by impaired cognition, communication, and sensory perception, behavioural abnormalities, seizure disorders, or a combination of these(More)
xi At Walter Reed Army Medical Center (WRAMC), a new generation of war-wounded soldiers is arriving with major limb amputation from the wars in Iraq and Afghanistan. More than 144 amputees from the Operations Iraqi Freedom and Operation Enduring Freedom (OIF/OEF) are being treated at WRAMC and the number is growing. The mission of the Department of Veterans(More)
Astrocytes are major sources of chemokines and are thus critical effectors of central nervous system (CNS) inflammation. However, it is as yet unclear whether these cells, like leukocytes, also possess receptors for chemokines (CCRs). To address this issue, we utilized a novel fluorescence approach to detect qualitatively and quantitatively binding sites(More)
As astrocytes are a source of monocyte chemoattractant protein-1 (MCP-1) and lie in close apposition to brain microvessels, interactions between astrocytes and infiltrating monocytes might regulate production of this chemokine. To investigate this possibility, a monocyte:astrocyte co-culture model was utilized to assess the respective roles of these two(More)
There are currently no cures for neurodegenerative diseases, including Batten disease, a rare and fatal disorder affecting young children. While researchers have made headway in preventing genetic disorders through preconception carrier screenings and have found potential drug targets, the gap between basic research and clinical treatment development(More)
Cultured fetal human cortical neurons derived from second trimester human fetal cortex were analyzed with regard to their morphological differentiation and expression of cell-specific markers. The culture method was adapted from standardized protocols originally developed for the isolation and culture of rodent oligodendrocytes and astrocytes. This(More)
Advances in robotic technology have led to an important crossroad regarding their applications to physical and rehabilitation medicine. One aspect of this crossroad is healthcare providers’ and the general public’s continuing eagerness to use “robotics” to enhance clinical and patient care. Body-weight support treadmill systems, bionic neurons (BIONsTM),(More)
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