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435 the contributors to better parse out the tensions within reproductive donation. And surprisingly , with the exception of one chapter, the contributors do not draw upon parallel discussions related to adoption, which may have a body of literature that could assist scholars in reproductive donation. However, on the whole, the book is a valuable(More)
Insulin secretion is associated with changes in pancreatic beta-cell K+ permeability. A degenerate polymerase chain reaction strategy based on the conserved features of known inwardly rectifying K+ (KIR) channel genes was used to identify members of this family expressed in human pancreatic islets and insulinoma. Three related human KIR transcript sequences(More)
PIH's goal of " accompaniment " to its patients as a means to ensure that medicine is taken and hardships are eased for those in need. The third section focuses on unnatural disasters, such as Hurricane Katrina and the earthquake that struck Haiti in 2010. More somber in tone, these speeches quickly got to Dr. Farmer's point that we, as doctors, scientists(More)
Major depression is a chronic and debilitating illness that effects approximately 1 in 5 people, but currently available treatments are limited by low rates of efficacy, therapeutic time lag, and undesirable side effects. Recent efforts have been directed towards investigating rapid-acting agents that reverse the behavioral and neuronal deficits of chronic(More)
Major depressive disorder (MDD) is a prevalent neuropsychiatric disease that causes profound social and economic burdens. The impact of MDD is compounded by the limited therapeutic efficacy and delay of weeks to months of currently available medications. These issues highlight the need for more efficacious and faster-acting treatments to alleviate the(More)
Resilience is an active process that involves a discrete set of neural substrates and cellular mechanisms and enables individuals to avoid some of the negative consequences of extreme stress. We have previously shown that dominant individuals show less stress-induced changes in behavior compared to subordinates using a conditioned defeat model in male(More)
Curcumin, a yellow-pigment compound found in the popular Indian spice turmeric (Curcuma longa), has been extensively investigated for its anti-inflammatory, chemopreventative, and antidepressant properties. Here, we examined the efficacy of dietary curcumin at impairing the consolidation and reconsolidation of a Pavlovian fear memory, a widely studied(More)
Major depressive disorder (MDD) is a recurring psychiatric illness that causes substantial health and socioeconomic burdens. Clinical reports have revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in individuals with MDD. Preclinical models suggest that these rapid antidepressant(More)
The CACNA1C gene that encodes the L-type Ca2+ channel (LTCC) Cav1.2 subunit has emerged as a candidate risk gene for multiple neuropsychiatric disorders including bipolar disorder, major depressive disorder, and schizophrenia, all marked with depression-related symptoms. Although cacna1c heterozygous (HET) mice have been previously reported to exhibit an(More)
The book's first few chapters deal with an introduction to bioinformatics, sequence analysis, and the diverse Internet resources currently available. The following chapters guide the reader through the databases of BLAST: BLASTN, BLASTP, BLASTX, and TBLASTN. Each chapter is set up to conduct you through a particular example query (or two), and is(More)