Danielle Guimarães

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Nitric oxide (NO)-derived metabolites including the anion nitrite can recycle back to NO and thus complement NO formation independent of NO synthases. While nitrite is as a major vascular storage pool and source of NO, little is known about drugs that increase tissue nitrite concentrations. This study examined the effects of atorvastatin or sildenafil, or(More)
Automated test case generation from behavioral models like Finite State Machines (FSMs) and Statecharts has long been studied. Environments that enable a test designer to model a real complex software and to obtain test cases to validate such a software are mandatory in an automated test approach. This paper presents an environment, GTSC, which enables test(More)
Imbalanced matrix metalloproteinase (MMP)-2 activity and transforming growth factor expression (TGF-β) are involved in vascular remodeling of hypertension. Atorvastatin and sildenafil exert antioxidant and pleiotropic effects that may result in cardiovascular protection. We hypothesized that atorvastatin and sildenafil alone or in association exert(More)
Distributed development of software has turned into a natural and modern approach where teams spread over the world cooperate to develop a software product, and this has become possible due to the expansion and popularity of global networks as internet. Collaborative tools coordinate a variety of tasks of several members of a team with an objective of(More)
Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increased xanthine oxidoreductase (XOR) activity mediates(More)
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