Danielle A. Williams

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To better understand the biology of hormone receptor-positive and-negative breast cancer and to identify methylated gene markers of disease progression, we carried out a genome-wide methylation array analysis on 103 primary invasive breast cancers and 21 normal breast samples, using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG(More)
BACKGROUND Elevated blood pressure (BP) is a major modifiable risk factor. However hypertension still remains underdiagnosed, untreated or suboptimally treated. This study aimed to identify and explore barriers to initiating medication and treating elevated BP to target levels in the general practice setting. METHODS Six focus groups involving 30(More)
BACKGROUND Class IA PI 3-kinases produce phosphatidylinositol (3,4,5)-trisphosphate (PIP3). PIP3 is bound by AKT which facilities its activation by PDK1. Activated AKT promotes cell survival and stimulates cell proliferation. Class IA PI 3-kinases are heterodimers consisting of a regulatory subunit p85 and a catalytic subunit p110. The p110alpha isoform has(More)
OBJECTIVE To explore the support needs and experiences of patients who had received publicly or privately funded bariatric surgery and the importance of this support in mediating outcomes of surgery. METHODS Seven semi-structured focus groups were conducted. A broad interview schedule guided the discussions which were audio-recorded and transcribed(More)
Myeloid progenitor-derived suppressor cells (MDSCs) arise from myeloid progenitors and suppress both innate and adaptive immunity. MDSCs expand during the later phases of sepsis in mice, promote immunosuppression, and reduce survival. Here, we report that the myeloid differentiation-related transcription factor nuclear factor I-A (NFI-A) controls MDSC(More)
Athletic compression apparel is becoming widely adopted at all levels of competition, but the performance benefits remain incompletely defined. The objective of this study was to assess the effect of custom-fit compression suits on agility, jump, and proprioceptive performance. Athletes were tested in three apparel conditions: loose-fitting shorts and shirt(More)
BACKGROUND Clinical placement for students of nursing is a central component of tertiary nursing programs but continues to be a complex and multifaceted experience for all stakeholders. OBJECTIVES This paper presents findings from a longitudinal 3-year study across multiple sites within the Australian context investigating the quality of clinical(More)
It is standard practice for the adult postoperative patient to be treated prophylactically for the risk of deep vein thrombosis formation after a surgical procedure. This is often done with a regimen of mechanical compression (TED hose, graduated compression stockings, pneumatic compression devices) or a subcutaneous anticoagulant medication. A commonplace(More)
BACKGROUND Despite efforts to achieve conceptual clarity, advanced practice nursing continues to reside in a liminal space, unable to secure ongoing recognition as a viable means of healthcare delivery. This is particularly evident in general practice where advanced practice role development is more fluid and generally less supported by the hierarchical(More)
Pseudomonas aeruginosa is an important pathogen of the immunocompromised, causing both acute and chronic infections. In cystic fibrosis (CF) patients, P. aeruginosa causes chronic disease. The impressive sensory network of P. aeruginosa allows the bacteria to sense and respond to a variety of stimuli found in diverse environments. Transcriptional(More)