Daniella Patrick

Learn More
OBJECTIVE Diabetogenic T-cell recruitment into pancreatic islets facilitates beta-cell destruction during autoimmune diabetes, yet specific mechanisms governing this process are poorly understood. The chemokine stromal cell-derived factor-1 (SDF-1) controls T-cell recruitment, and genetic polymorphisms of SDF-1 are associated with early development of type(More)
The effect of captopril, furosemide, indomethacin and intake of sodium on the production of PGI2-like material was studied in the rat aorta. Release of PGI2-like material from these vessels was estimated by its ability to inhibit ADP-induced platelet aggregation. Pretreatment with indomethacin (15 mg/kg/day) reduced the capacity of the aorta to release(More)
OBJECTIVE Insulitis is an important pathological feature of autoimmune diabetes; however, mechanisms governing the recruitment of diabetogenic T-cells into pancreatic islets are poorly understood. Here, we determined the importance of leukocyte integrins beta(2)(Itgb2) and alphaL (ItgaL) in developing insulitis and frank diabetes. RESEARCH DESIGN AND(More)
The effect of dietary sodium manipulation was studied In 27 normal subjects and 19 patients with borderline hypertension. Sodium-loading caused an Increase in blood pressure (BP) in 14 of 19 borderline hypertensive patients but in only 4 of 27 normal subjects (X* = 13.85, p < 0.01). In the normal subjects, a 10 mEq sodium diet resulted in a fall in supine(More)
The origin, physiological role, and metabolism of the serum polysaccharides are largely unknown, and their relationship to changes which occur in connective tissue is not yet firmly established. The occurrence of polysaccharide material in connective tissue has been amply demonstrated by isolation and histochemical methods. Using histochemical methods, an(More)
Nine patients with resistant hypertension received captopril for 12 months. Five received captopril alone, four required additional therapy. In the former, mean blood pressure fell from 109 +/- 4.2 mm Hg to 84 +/- 7.5 mm Hg (P less than 0.025) after seven days. A rise to 101 +/- 19 mm Hg was noted at six and 12 months. Total peripheral resistance fell at(More)
While robotic hands have been developed for manipulation and grasping, their potential as tools for performance evaluation of engineered products - particularly compliant garments that are not easily modeled - has not been broadly studied. In this research, the development of a low-cost anthropomorphic robotic hand is introduced that is designed to(More)