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The validation of Calophyllum brasiliense (“guanandi”) uses in Brazilian traditional medicine as analgesic by in vivo antinociceptive evaluation and its chemical analysis
TRPV1 channels play an important role in the mechanism of action of the chloroform fraction of C. brasiliense (CFCB) roots and 1,2-dimethoxyxanthone largely contributes to the antinociceptive effect of CFCB.