The representation of a biochemical system as a network is the precursor of any mathematical model of the processes driving the dynamics of that system. Pharmacokinetics uses mathematical models to describe the interactions between drug, and drug metabolites and targets and through the simulation of these models predicts drug levels and/or dynamic behaviors… (More)
We present CoSBiLab BlenX as a development and analysis platform for modeling pharmacodynamical systems. Together with its supporting tool CoSBiLab KInfer for inferring kinetic parameters, BlenX provides an effective compromise between the differential equations-based and mechanisms-based approaches to modeling of pharmacodynamical systems. In this paper,… (More)
Gemcitabine (2,2-difluorodeoxycytidine, dFdC) is a prodrug widely used for treating various carcinomas. Gemcitabine exerts its clinical effect by depleting the deoxyribonucleotide pools, and incorporating its triphosphate metabolite (dFdC-TP) into DNA, thereby inhibiting DNA synthesis. This process blocks the cell cycle in the early S phase, eventually… (More)
We present a model written in BlenX language describing the lung tumor size changes over the time course of chemotherapy in human patients that are treated with gemcitabine and carboplatin.
Reaction-diffusion based models have been widely used in the literature for modeling the growth of solid tumors. Many of the current models treat both diffusion/consumption of nutrients and cell proliferation. The majority of these models use classical transport/mass conservation equations for describing the distribution of molecular species in tumor… (More)