Daniele Fernandes de Aguiar

Learn More
Rapid adaptive fixation of a new favorable mutation is expected to affect neighboring genes along the chromosome. Evolutionary theory predicts that the chromosomal region would show a reduced level of genetic variation and an excess of rare alleles. We have confirmed these predictions in a region of the X chromosome of Drosophila melanogaster that contains(More)
Rodents with lesion of dopaminergic pathway when receiving repeated l-3,4-dihydroxiphenylalanine (l-DOPA) treatment develop abnormal involuntary movements called dyskinesia. We demonstrated that nitric oxide synthase (NOS) inhibitors mitigate l-DOPA-induced dyskinesia in rodents. The aim of the present study was to verify if the in vivo preferential(More)
The diagnosis of early signs of Alzheimer's disease (AD) is a major challenge in a heterogeneous population. Objective To investigate the use of the Brief Cognitive Screening Battery (BCSB) for the diagnosis of mild AD in a geriatric outpatient unit of a public hospital in the city of Rio de Janeiro. Method BCSB was administered to 51 elderly adults with a(More)
The present study is a report on the authors' experience working nurses in a randomized, blinded, phase III clinical trial, developed at Escola Nacional de Saúde Pública Sérgio Arouca / FIOCRUZ / RJ. This study describes the participation of nurses in the implementation of a clinical trial, highlighting their importance in this new field of work. The(More)
  • 1