Daniele Fabris

Nathan A. Hagan2
John P. Marino2
Kevin B. Turner2
2Nathan A. Hagan
2John P. Marino
2Kevin B. Turner
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Since its inception in 1994, The RNA Modification Database (RNAMDB, http://rna-mdb.cas.albany.edu/RNAmods/) has served as a focal point for information pertaining to naturally occurring RNA modifications. In its current state, the database employs an easy-to-use, searchable interface for obtaining detailed data on the 109 currently known RNA modifications.(More)
  • Robert J. Fisher, Matthew J. Fivash, Andrew G. Stephen, Nathan A. Hagan, Shilpa R. Shenoy, Maxine V. Medaglia +11 others
  • 2006
The HIV-1 nucleocapsid (NC) protein is a small, basic protein containing two retroviral zinc fingers. It is a highly active nucleic acid chaperone; because of this activity, it plays a crucial role in virus replication as a cofactor during reverse transcription, and is probably important in other steps of the replication cycle as well. We previously(More)
  • Kevin B. Turner, Robert G. Brinson, Hye Young Yi-Brunozzi, Jason W. Rausch, Jennifer T. Miller, Stuart F.J. Le Grice +2 others
  • 2008
The interactions of archetypical nucleic acid ligands with the HIV-1 polypurine tract (PPT) RNA:DNA hybrid, as well as analogous DNA:DNA, RNA:RNA and swapped hybrid substrates, were used to probe structural features of the PPT that contribute to its specific recognition and processing by reverse transcriptase (RT). Results from intercalative and(More)
Fig. 1s: Ligand-SL3 binding curves. For the sake of clarity, only one representative curve is shown for each class of ligands: neomycin B („), ethidium bromide (z), mitoxantrone (▲), distamycin A (), and chlorotetracycline (‹). See Materials and Methods for conditions. Fig. 2s: Ligand-SL4 binding curves. For the sake of clarity, only one representative(More)
Although polypurine tract (PPT)-primed initiation of plus-strand DNA synthesis in retroviruses and LTR-containing retrotransposons can be accurately duplicated, the molecular details underlying this concerted series of events remain largely unknown. Importantly, the PPT 3' terminus must be accommodated by ribonuclease H (RNase H) and DNA polymerase(More)
Disrupting the interactions between human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) protein and structural elements of the packaging signal (Psi-RNA) could constitute an ideal strategy to inhibit the functions of this region of the genome leader in the virus life cycle. We have employed electrospray ionization (ESI) Fourier transform mass(More)
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