Daniele D ’ Armiento

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Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2/IGH rearrangements were found in three cases; HLA-DRB1*07 in all. Bone marrow (BM) trephines showed a moderate lymphoid infiltrate with intrasinusoidal distribution resembling a splenic marginal-zone lymphoma. Splenic(More)
Sickle cell anemia (SCA) remains associated with high risks of morbidity and early death. Allogeneic hematopoietic SCT (HSCT) is the only curative treatment for SCA. We report our experience with transplantation in a group of patients with the non-Black African variant and the Black African variant of SCA. This study included 40 consecutive SCA patients (13(More)
In patients with chronic lymphocytic leukemia (CLL), a family history of hematologic malignancies is recorded in 12% of cases, half of the latter being CLL.1 First-degree relatives of CLL patients have an 8-fold greater likelihood of harboring a CLL than members of the general population.2 Monoclonal B cells with a CLL-like immunophenotype, defined as(More)
A comprehensive panel of clinical-biological parameters was prospectively evaluated at presentation in 112 patients with chronic lymphocytic leukemia (<65 years), to predict the risk of progression in early stage disease. Eighty-one percent were in Binet stage A, 19% in stages B/C. Treatment-free survival was evaluated as the time from diagnosis to first(More)
BACKGROUND AND PURPOSE Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for sickle cell anemia (SCA). We report our experience with transplantation in children with the Black African variant of SCA and the effects of transplant on erythroid compartment in bone marrow (BM). PATIENTS AND METHODS Twenty-seven(More)
Bone marrow transplantation (BMT) performance can be limited by a lack of ideal donors, and the role of alternative donor hematopoietic cell transplantation in thalassemia is not well established. Here we used a new treatment protocol (Pc 26.1) in 16 thalassemia patients to perform BMT using phenotypically HLA-identical or 1-antigen-mismatched relatives(More)
UHECR may be either nucleons [2] or nuclei; in the latter case the Lightest Nuclei, as He or He, Li, Be , explains at best the absence of Virgo signals and the crowding of events around Cen-A bent by galactic magnetic fields [3]. This model fit the observed nuclear mass composition discovered in AUGER. However UHECR nucleons above GZK produce EeV neutrinos(More)